Rationale: Although occupational exposure to dust and fumes is considered a risk factor for
chronic obstructive pulmonary disease, this determination has been limited by reliance on …

Rationale: Ever-smokers without airflow obstruction scores greater than or equal to 10 on
the COPD Assessment Test (CAT) still have frequent acute respiratory disease events …

Background Emphysema is a key contributor to airflow limitation in chronic obstructive
pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the …

Purpose To evaluate the relationships between DL CO, and Quantitative CT (QCT)
measurements and visual assessment of pulmonary emphysema and to test the relative …

Computed tomography (CT) has contributed substantially to our understanding of COPD
over the past decade. Visual and quantitative assessments of CT in COPD are …

Background Gas trapping quantified on chest CT scans has been proposed as a surrogate
for small airway disease in COPD. We sought to determine if measurements using paired …

Current epidemiologic practice evaluates COPD based on self-reported symptoms of
chronic bronchitis, self-reported physician-diagnosed COPD, spirometry confirmed airflow …

Although the human and societal burden and cost of COPD is staggering, there are few
clinical tools that provide earlier diagnoses or a means to regionally monitor disease in a …

Background Emphysema and small airway disease both contribute to chronic obstructive
pulmonary disease (COPD), a disease characterised by accelerated decline in lung …

Rationale: Quantitative computed tomography (CT) has been used to phenotype patients
with chronic obstructive pulmonary disease (COPD). A mixed phenotype is defined as the …