GRN, the gene coding for the progranulin (PGRN) protein, was recognized as a gene linked
to frontotemporal lobar degeneration (FTLD). The first mutations identified were null …

Gene coding for progranulin, GRN, is a major gene linked to frontotemporal lobar
degeneration. While most of pathogenic GRN mutations are null mutations leading to …

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar
degeneration (FTLD). Most known GRN mutations are null mutations, such as nonsense and …

Recently, mutations in the progranulin gene (GRN) were reported to account for the vast
majority of Frontotemporal lobar Degeneration (FTLD) and a growing number of reports …

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease with
an age at onset generally below 65 years. Mutations in progranulin (GRN) have been …

Mutations in progranulin gene (GRN) are a common cause of autosomal dominant
frontotemporal lobar degeneration and are associated with a wide phenotypic …

Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in
progressive decline in behavior, executive function and sometimes language. Disease …

Background: Progranulin protein (PGRN) is a cysteine-rich growth factor encoded by the
progranulin gene (GRN). PGRN mutations were identified in patients with frontotemporal …

Null mutations in the progranulin gene (PGRN) were recently reported to cause tau-negative
frontotemporal dementia linked to chromosome 17. We assessed the genetic contribution of …

Objective Mutations that lead to a loss of progranulin (PGRN) explain a considerable portion
of the occurrence of frontotemporal lobar degeneration. We tested a biomarker allowing …