Impaired protein degradation has been discussed as a cause or consequence of various
neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's disease …

Neuronal cell death is the main pathological feature of chronic neurodegenerative diseases
(NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral …

Autophagy is a degradation pathway for long-lived cytoplasmic proteins, protein complexes,
or damaged organelles. The accumulation and aggregation of misfolded proteins are …

Protein degradation plays a central role in many cellular functions. Misfolded and damaged
proteins are removed from the cells to avoid toxicity. Eukaryotic cells have two main routes …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin‐positive
inclusions are neurodegenerative disorders that share the cytosolic deposition of TDP‐43 …

At the cellular level, many neurodegenerative diseases (NDs), often considered
proteinopathies, are characterized by the accumulation of misfolded and damaged proteins …

Most neurodegenerative diseases involve the accumulation of misfolded proteins in the
nervous system. Impairment of protein degradation pathways such as autophagy is …

Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson
disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative disorders that share genetic risk factors and pathological hallmarks …