In humans, nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA
double-strand breaks are repaired. Recognition of each broken DNA end by the DNA repair …

XRCC4 and DNA ligase IV form a complex that is essential for the repair of all double‐strand
DNA breaks by the nonhomologous DNA end joining pathway in eukaryotes. We find here …

Repair of DNA double strand breaks (DSB) by the nonhomologous end-joining pathway in
mammals requires at least seven proteins involved in a simplified two-step process:(i) …

The double-strand DNA break repair pathway, non-homologous DNA end joining (NHEJ), is
distinctive for the flexibility of its nuclease, polymerase and ligase activities. Here we find that …

Nonhomologous end-joining represents the major pathway used by human cells to repair
DNA double-strand breaks. It relies on the XRCC4/DNA ligase IV complex to reseal DNA …

Repair of DNA double-strand breaks in mammalian cells occurs via a direct nonhomologous
end-joining pathway. Although this pathway can be studied in vivo and in crude cell-free …

DNA non-homologous end-joining (NHEJ) is a major mechanism for repairing DNA double-
stranded (ds) breaks in mammalian cells. Here, we characterize the interaction between two …

The efficient repair of DNA double-strand breaks (DSBs) is critical for the maintenance of
genomic integrity. In mammalian cells, the nonhomologous end-joining process that …

Nonhomologous end joining (NHEJ) is the principal mechanism for repairing DNA double-
strand breaks in mammalian cells. NHEJ requires at least three protein components: the …

Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double-strand
breaks (DSBs) in mammalian cells. DNA-dependent protein kinase (DNA-PK), ligase IV, and …