Various roles for the viral receptor, CD4, have been proposed in facilitating human
immunodeficiency virus type 1 (HIV-1) entry, including virion binding to the target cell and …

CD4 functions as the cell-surface receptor for human immunodeficiency virus (HIV);
however, the mechanism of virus entry into susceptible cells is unknown. To explore this …

The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …

Neutralization of human immunodeficiency virus type 1 (HIV-1) infection with soluble CD4
(sCD4) can be achieved over a broad range of concentrations for different virus strains …

HIV-1 generates remarkable intra-and inter-host viral diversity during infection. In the
response to the dynamic selective pressures of the host's environment, HIV-1 evolves …

An HIV-1 infection in a host cell occurs through an ordered process that involves HIV-1
attachment to the host's cellular CD4 receptor, co-receptor binding to CCR5 or CXCR4, and …

Entry of HIV-1 into target cells involves the interaction of the HIV envelope (Env) with both a
primary receptor (CD4) and a coreceptor (CXCR4 or CCR5). The relative efficiency with …

CD4 and members of the chemokine receptor family are required for infection of host cells,
in vitro and in vivo, by the human immunodeficiency virus type-1. Although it is established …

HIV infection of chimpanzees results in a chronic viremia unaccompanied by the ultimately
fatal immunodeficiency that marks HIV infection in man. We show here that expression of …

To characterize the role of CD4 in human immunodeficiency virus type 1 (HIV-1) infection of
macrophages, we examined the expression of CD4 by primary human monocyte-derived …