DNA damage repair plays a key role in maintaining genomic stability and integrity. Flap
endonuclease 1 (FEN1) is a core protein in the base excision repair (BER) pathway and …

Abstract DNA flap endonuclease 1 (FEN1) plays critical roles in maintaining genome
stability and integrity by participating in both DNA replication and repair. Suppression of …

Lung cancer is one of the leading causes of cancer mortality worldwide. The therapeutic
effect of chemotherapy is limited due to the resistance of cancer cells, which remains a …

There have been several recent reports of chemopotentiation via inhibition of DNA repair
processes. Flap endonuclease 1 (FEN1) is a key enzyme involved in base excision repair …

FEN1, a key participant in DNA replication and repair, is the major human flap
endonuclease that recognizes and cleaves flap DNA structures. Deficiencies in FEN1 …

Flap endonuclease-1 (FEN1) is a highly conserved metallonuclease and is the main human
flap endonuclease involved in the recognition and cleavage of single-stranded 5 …

Abstract Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that
has a critical role in maintaining human genome stability. FEN1 mutations have been …

Flap endonuclease 1 (FEN1) plays a crucial role in both DNA replication and damage
repair. In this study, FEN1 expression and its clinical-pathologic significance in non–small …

Flap endonuclease-1 (FEN1) is a key enzyme involved in base excision repair (BER), a
primary pathway utilized by mammalian cells to repair DNA damage. Sensitization to DNA …

Background Drug resistance is a major challenge in cancer therapeutics. Abundant
evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic …