Purpose: This study was conducted to determine whether paeoniflorin (PF) could prevent
H2O2-induced oxidative stress in ARPE-19 cells and to elucidate the molecular pathways …

Abnormal accumulation of the free-form all-trans-retinal (atRAL), a major intermediate of
human visual cycle, is considered to be a key cause of retinal pigment epithelial (RPE) …

Eupatilin, a pharmacologically active flavone derived from the Artemisia plant species, is
known to possess anti-oxidant activity. However, the effects of eupatilin on oxidative stress …

The protection of retinal pigment epithelium (RPE) injury plays an important role in the
prevention of or in delaying the pathological progress of retinal degeneration diseases, like …

Purpose Oxidative stress-induced damage to RPE cells has been suggested to be an
important factor in the pathogenesis of age-related macular degeneration. Taxifolin, a …

The aim of present study is to investigate whether Ferulic acid (FA), a natural polyphenol
antioxidant, was able to protect ARPE‑19 cells from hydrogen peroxide (H2O2)‑induced …

Abstract Isorhamnetin, a 3‑O‑methylated metabolite of quercetin, exhibits antioxidant effects.
However, to the best of our knowledge, no study to date has focused on the effects of …

Purpose: Age-related macular degeneration is a leading cause of blindness in the elderly. At
a later stage, neovascular or exudative age-related macular degeneration can lead to …

Degeneration of retinal pigment epithelial (RPE) cells is a clinical hallmark of age-related
macular degeneration (AMD), the leading cause of blindness among aged people in the …

Age-related macular degeneration (AMD) is a complex multifactorial disease associated
with the dysfunction of retinal pigment epithelium (RPE). Aloperine is a quinolizidine alkaloid …