Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications

H Kim, S Kim, SJ Shin, YH Park, Y Nam, C Kim… - Translational …, 2021 - Springer
Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and
causes destructive and irreversible cognitive decline. Failures in the development of …

Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer's disease brain: a review

X Zhan, B Stamova, FR Sharp - Frontiers in aging neuroscience, 2018 - frontiersin.org
This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …

The possibility of an infectious etiology of Alzheimer disease

GM Ashraf, VV Tarasov, A Makhmutovа… - Molecular …, 2019 - Springer
Over the past three decades, there has been constant postulation regarding the infectious
etiology of Alzheimer disease (AD), which in turn suggests the vital role of various infectious …

Clinical evidence of human pathogens implicated in Alzheimer's disease pathology and the therapeutic efficacy of antimicrobials: An overview

CSG Catumbela, VV Giridharan, T Barichello… - Translational …, 2023 - Springer
A wealth of pre-clinical reports and data derived from human subjects and brain autopsies
suggest that microbial infections are relevant to Alzheimer's disease (AD). This has inspired …

Link between chronic bacterial inflammation and Alzheimer disease

F Bibi, M Yasir, S S. Sohrab, E I. Azhar… - CNS & Neurological …, 2014 - benthamdirect.com
Alzheimer's disease (AD) is a degenerative disease of brain that is associated with
dementia, brain atrophy, accumulation of hyperphosphorylated tau protein and amyloid-beta …

Multi-pathogen infections and Alzheimer's disease

D Vigasova, M Nemergut, B Liskova… - Microbial Cell Factories, 2021 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with the
overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau …

[HTML][HTML] Pathogenic microbes, the microbiome, and Alzheimer's disease (AD)

JM Hill, C Clement, AI Pogue… - Frontiers in aging …, 2014 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of cognitive and behavioral impairment in industrialized societies. The cause of AD is …

Emerging roles of pathogens in Alzheimer disease

J Miklossy - Expert reviews in molecular medicine, 2011 - cambridge.org
Chronic spirochetal infection can cause slowly progressive dementia, cortical atrophy and
amyloid deposition in the atrophic form of general paresis. There is a significant association …

Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease brain

Y Zhao, L Cong, V Jaber, WJ Lukiw - Frontiers in Immunology, 2017 - frontiersin.org
Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological
data together indicate that there occur an unusual inflammatory reaction and a disruption of …

Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer's Disease

WJ Lukiw - Frontiers in microbiology, 2016 - frontiersin.org
The human microbiome consists of~ 3.8× 1013 symbiotic microorganisms that form a highly
complex and dynamic ecosystem: the gastrointestinal (GI) tract constitutes the largest …