AIDS is among the most devastating diseases of our time, claiming the lives of
approximately 3 million people per year. The primary cause of AIDS, human …

The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …

Tremendous advances in our understanding of the human immunodeficiency viruses (HIVs)
have been made through the use of animal models. However, there are limitations inherent …

Human immunodeficiency virus (HIV) remains a significant source of morbidity and mortality
worldwide. No effective vaccine is available to prevent HIV transmission, and although …

Highlights•HIV the causative agent of AIDS has an extremely limited tropism and does not
replicate in mice, rats or non-human primates.•Humanized mouse models contain different …

In this review, we describe the most recent advances in the use of animal models for
HIV/AIDS research, and will break down these advances in three areas: models for virus …

Several nonhuman primate models are used in HIV/AIDS research. In contrast to natural
host models, infection of macaques with virulent simian immunodeficiency virus (SIV) …

The absence of a suitable animal model has remained one of the major barriers to the
development of an effective therapy for HIV-1 infection. Ideally, a small and readily available …

Because of the limited tropism of HIV, in vivo modeling of this virus has been almost
exclusively limited to other lentiviruses such as SIV that reproduce many important …

Animal models of HIV infection have played an important role in the development of
antiretroviral drugs. Although each animal model has its limitations and never completely …