DNA methylation signatures of bone metabolism in osteoporosis and osteoarthritis aging-related diseases: an updated review
VV Visconti, I Cariati, S Fittipaldi, R Iundusi… - International Journal of …, 2021 - mdpi.com
DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …
regulating gene expression. The epigenetic component is strongly involved in aging-bone …
The influence of DNA methylation on bone cells
S Reppe, H Datta, KM Gautvik - Current genomics, 2015 - ingentaconnect.com
DNA methylation in eukaryotes invokes heritable alterations of the of the cytosine base in
DNA without changing the underlying genomic DNA sequence. DNA methylationmay be …
DNA without changing the underlying genomic DNA sequence. DNA methylationmay be …
The role of DNA methylation in common skeletal disorders
J Delgado-Calle, JA Riancho - Biology, 2012 - mdpi.com
Bone is a complex connective tissue characterized by a calcified extracellular matrix. This
mineralized matrix is constantly being formed and resorbed throughout life, allowing the …
mineralized matrix is constantly being formed and resorbed throughout life, allowing the …
[HTML][HTML] DNA methylation in osteoarthritis: current status and therapeutic implications
A Miranda-Duarte - The open rheumatology journal, 2018 - ncbi.nlm.nih.gov
Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …
are strongly associated with its development; however, recently it has been observed that …
[HTML][HTML] DNA methylation in osteoarthritic chondrocytes: a new molecular target
HI Roach, T Aigner - Osteoarthritis and cartilage, 2007 - Elsevier
OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …
association with transcriptional silencing, possible mechanisms of hyper-and …
Identification of genes with altered methylation in osteoclast differentiation and its roles in osteoporosis
R Peng, Y Dong, H Kang, Q Guo, M Zhu… - DNA and Cell Biology, 2022 - liebertpub.com
Osteoporosis is one of the most common metabolic skeletal diseases, which affects more
than 200 million people worldwide, especially elderly and postmenopausal women. One of …
than 200 million people worldwide, especially elderly and postmenopausal women. One of …
Primary osteoporosis is not reflected by disease‐specific DNA methylation or accelerated epigenetic age in blood
E Fernandez‐Rebollo, M Eipel, L Seefried, P Hoffmann… - 2018 - academic.oup.com
Osteoporosis is an age‐related metabolic bone disease. Hence, osteoporotic patients might
suffer from molecular features of accelerated aging, which is generally reflected by specific …
suffer from molecular features of accelerated aging, which is generally reflected by specific …
[HTML][HTML] Systemic analysis of osteoblast-specific DNA methylation marks reveals novel epigenetic basis of osteoblast differentiation
F Yu, H Shen, HW Deng - Bone Reports, 2017 - Elsevier
DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …
commitment and specific functions of different cell types. In this study, we compared …
Progress on the role of DNA methylation in aging and longevity
FH Xiao, QP Kong, B Perry, YH He - Briefings in functional …, 2016 - academic.oup.com
Aging is a major risk factor for individuals' health problems. Moreover, environmental signals
have a widespread influence on the aging process. Epigenetic modification, eg DNA …
have a widespread influence on the aging process. Epigenetic modification, eg DNA …
Identification of an epigenetic signature of osteoporosis in blood DNA of postmenopausal women
Osteoporosis is one of the most common age‐related progressive bone diseases in elderly
people. Approximately one in three women and one in five men are predisposed to …
people. Approximately one in three women and one in five men are predisposed to …