The role of epigenomics in osteoporosis and osteoporotic vertebral fracture
Osteoporosis is a complex multifactorial condition of the musculoskeletal system.
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …
Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical …
Epigenetic regulation of skeletal tissue integrity and osteoporosis development
YS Chen, WS Lian, CW Kuo, HJ Ke, SY Wang… - International Journal of …, 2020 - mdpi.com
Bone turnover is sophisticatedly balanced by a dynamic coupling of bone formation and
resorption at various rates. The orchestration of this continuous remodeling of the skeleton …
resorption at various rates. The orchestration of this continuous remodeling of the skeleton …
Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis
A Del Real, FM Pérez-Campo, AF Fernández… - Epigenetics, 2017 - Taylor & Francis
Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …
Epigenetic mechanisms of bone regeneration and homeostasis
Y Liu, XL Zhang, L Chen, X Lin, D Xiong, F Xu… - Progress in Biophysics …, 2016 - Elsevier
Bone regeneration is a promising avenue for osteoporosis (OP) treatment. It consists of
several procedures, such as the osteogenic differentiation of mesenchymal stem cells as …
several procedures, such as the osteogenic differentiation of mesenchymal stem cells as …
Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications
A Cribbs, M Feldmann… - Therapeutic advances in …, 2015 - journals.sagepub.com
The term 'epigenetics' loosely describes DNA-templated processes leading to heritable
changes in gene activity and expression, which are independent of the underlying DNA …
changes in gene activity and expression, which are independent of the underlying DNA …
Epigenome-wide cross-tissue correlation of human bone and blood DNA methylation–can blood be used as a surrogate for bone?
P Ebrahimi, H Luthman, FE McGuigan, KE Akesson - Epigenetics, 2021 - Taylor & Francis
Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–
environment interactions, and their role in disease pathogenesis. Blood is an obvious …
environment interactions, and their role in disease pathogenesis. Blood is an obvious …
Recent advances in the epigenetics of bone metabolism
Osteoporosis is a common form of metabolic bone disease that is costly to treat and is
primarily diagnosed on the basis of bone mineral density. As the influences of genetic …
primarily diagnosed on the basis of bone mineral density. As the influences of genetic …
DNA methylation in osteoarthritis
W den Hollander, I Meulenbelt - Current Genomics, 2015 - ingentaconnect.com
Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by
degradation and calcification of articular cartilage. Presently, no effective treatment other …
degradation and calcification of articular cartilage. Presently, no effective treatment other …
Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage
O Alvarez‐Garcia, KM Fisch… - Arthritis & …, 2016 - Wiley Online Library
Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …
cartilage and to determine the role of DNA methylation in the regulation of gene expression …
[HTML][HTML] Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease?
LN Reynard - Seminars in Cell & Developmental Biology, 2017 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …