Epigenetic modification pertains to the alteration of genetic-expression, which could be
transferred to the next generations, without any alteration in the fundamental DNA …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …

To elucidate the mechanisms related to the development of type 2 diabetes (T2D) and other
degenerative diseases at a molecular level, a better understanding of the changes in the …

Background Osteoarthritis is a chronic musculoskeletal disease characterized by age-
related gradual thinning and a high risk in females. Recent studies have shown that DNA …

The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …

Epigenetic modifications are heritable changes in gene expression without changes in DNA
sequence. DNA methylation has been implicated in the control of several cellular processes …

Abstract Purpose of Review Epigenetic mechanisms modify gene activity in a stable manner
without altering DNA sequence. They participate in the adaptation to the environment, as …

Aging as an inevitable phenomenon is associated with pervasive changes in physiological
functions. There is a relationship between aging and the increase of several chronic …

Osteoporosis is a systemic disease characterized by low bone mass and microarchitectural
deterioration of bone tissue, with a consequent increase in bone fragility and propensity to …