Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Objectives Rheumatic diseases encompass a wide range of conditions of poorly
characterized etiopathology, many having both genetic and environmental susceptibility …

Methylation of cytosine residues in DNA, the best studied epigenetic modification, is
associated with gene transcription and nuclear organization, and ultimately the function of a …

The aim of this study was to evaluate whether genome-wide levels of DNA methylation are
associated with age and the health risks of obesity (HRO); defined according to BMI …

Purpose: As the population ages, there is an increased risk of fracture and morbidity
diseases associated with aging, such as age-related osteoporosis and other bone diseases …

Bone remodeling is a continuous and dynamic process of bone formation and resorption to
maintain its integrity and homeostasis. Bone marrow is a source of various cell lineages …

The role and underlying mechanisms of DNA methylation in osteogenesis/chondrogenesis
remain poorly understood. We here reveal DNA methyltransferase 1 (DNMT1), which is …

Background Age-associated changes in genomic DNA methylation have been primarily
attributed to 5-methylcytosine (5mC). However, the recent discovery of 5 …

Background The elderly population is at risk of osteoarthritis (OA), a common, multifactorial,
degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA …

Background Traditionally, the diagnosis and monitoring of disease activity in systemic lupus
erythematosus (SLE) are contingent upon clinical manifestations and serological markers …