Background Age-associated changes in genomic DNA methylation have been primarily
attributed to 5-methylcytosine (5mC). However, the recent discovery of 5 …

Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …

Background Traditionally, the diagnosis and monitoring of disease activity in systemic lupus
erythematosus (SLE) are contingent upon clinical manifestations and serological markers …

Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …

Knee osteoarthritis (OA) is a leading cause of chronic disability worldwide, but no diagnostic
or prognostic biomarkers are available. Increasing evidence supports epigenetic …

To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …

Purpose: Aging is one of the most important risk factors for a number of human diseases.
Epigenetic alterations, including changes in DNA methylation patterns, have been reported …

Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic
mechanisms including DNA methylation. Methylation changes may also play a key role in …

Osteoarthritis (OA) is the most common form of arthritis worldwide. It is a complex disease
affecting the whole joint but is generally characterized by progressive degradation of …

Genomic predisposition cannot explain the onset of complex diseases, as well illustrated by
the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms …