TGF-β, IL-1β, IL-6 levels and TGF-β/Smad pathway reactivity regulate the link between allergic diseases, cancer risk, and metabolic dysregulations

Z Elkoshi - Frontiers in Immunology, 2024 - frontiersin.org
The risk of cancer is higher in patients with asthma compared to those with allergic rhinitis
for many types of cancer, except for certain cancers where a contrasting pattern is observed …

TGF‐β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development

B Tirado-Rodriguez, E Ortega… - Journal of …, 2014 - Wiley Online Library
The transforming growth factor‐β (TGF‐β) superfamily is a family of structurally related
proteins that includes TGF‐β, activins/inhibins, and bone morphogenic proteins (BMPs) …

Metabolism of epithelial cells in health and allergic disease: Collegium Internationale Allergologicum Update 2021

AM Queener, SE Chiarella, L Cuervo-Pardo… - International archives of …, 2021 - karger.com
Concomitant dramatic increase in prevalence of allergic and metabolic diseases is part of a
modern epidemic afflicting technologically advanced societies. While clinical evidence …

Inhibition of tumor progression during allergic airway inflammation in a murine model: significant role of TGF-β

B Tirado-Rodriguez, G Baay-Guzman… - Cancer Immunology …, 2015 - Springer
Introduction TGF-β is an important mediator of pulmonary allergic inflammation, and it has
been recently reported to be a potential inhibitor of lung tumor progression. The correlation …

Transcriptomics reveals a distinct metabolic profile in T cells from severe allergic asthmatic patients

C Pablo-Torres, C Garcia-Escribano, M Romeo… - Frontiers in …, 2023 - frontiersin.org
The reasons behind the onset and continuation of chronic inflammation in individuals with
severe allergies are still not understood. Earlier findings indicated that there is a connection …

The importance of metabolism for immune homeostasis in allergic diseases

J Rodriguez-Coira, A Villaseñor, E Izquierdo… - Frontiers in …, 2021 - frontiersin.org
There is increasing evidence that the metabolic status of T cells and macrophages is
associated with severe phenotypes of chronic inflammation, including allergic inflammation …

Unveiling the TGF-β1 paradox: significant implication of TGF-β1 promoter variants and its mRNA and protein expression in atopic dermatitis

T Shafi, R Rasool, S Ayub, IA Bhat, IH Shah… - Molecular …, 2023 - Elsevier
Abstract Background Atopic Dermatitis (AD) is a chronic inflammatory skin disorder with
evidence of lichenification in later stages. There is mounting evidence supporting the role of …

TGF-β gene polimorphisms as risk factors for asthma control among clinic patients

P Michał, S Konrad, K Piotr - Journal of Inflammation, 2021 - Springer
Background TGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial
hyperreactivity, and bronchial remodeling. Expression of isoforms 1–3 of TGFβ cytokine is …

Immune metabolism in allergies, does it matter?—A review of immune metabolic basics and adaptations associated with the activation of innate immune cells in …

A Goretzki, YJ Lin, S Schülke - Allergy, 2021 - Wiley Online Library
Type I allergies are pathological, type 2 inflammatory immune responses against otherwise
harmless environmental allergens that arise from complex interactions between different …

In Vivo Disruption of TGF-β Signaling by Smad7 in Airway Epithelium Alleviates Allergic Asthma but Aggravates Lung Carcinogenesis in Mouse

X Luo, Q Ding, M Wang, Z Li, K Mao, B Sun, Y Pan… - PLoS …, 2010 - journals.plos.org
Background TGF-β has been postulated to play an important role in the maintenance of
epithelial homeostasis and the development of epithelium-derived cancers. However, most …