Altered DNA methylation upon ageing may result in many age‐related diseases such as
osteoporosis. However, the changes in DNA methylation that occur in cortical bones, the …

DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …

DNA methylation in eukaryotes invokes heritable alterations of the of the cytosine base in
DNA without changing the underlying genomic DNA sequence. DNA methylationmay be …

Osteoporosis is an age-related, systemic skeletal disease that poses a significant public
health challenge in contemporary society. Development at the epigenetic level is emerging …

Bone mass can change intra-individually due to aging or environmental factors.
Understanding the regulation of bone metabolism by epigenetic factors, such as DNA …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Osteoporosis is one of the most common metabolic skeletal diseases, which affects more
than 200 million people worldwide, especially elderly and postmenopausal women. One of …

Osteoporosis is a disease that impacts the elderly. Low estrogen is related to changes in
DNA methylation and consequent alterations in gene expression, leading to a new direction …

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

Osteoporosis is characterized by systemic microarchitecture impairment and bone loss,
which ultimately lead to fragility fractures. This disease is most common in older people …