Alterations to the human organism that are brought about by aging are comprehensive and
detrimental. Of these, an imbalance in bone homeostasis is a major outward manifestation of …

A number of epigenetic studies have demonstrated that DNA methylation patterns exhibit a
tissue specificity, but not much has been done to highlight the extent of this phenomenon …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Bone regeneration is a promising avenue for osteoporosis (OP) treatment. It consists of
several procedures, such as the osteogenic differentiation of mesenchymal stem cells as …

Senile osteoporosis increases fracture risks. Bone marrow stromal cells (BMSCs) are
sensitive to aging. Deep insights into BMSCs aging are vital to elucidate the mechanisms …

Differences in DNA methylation patterns have been observed among individuals of
disparate ages in both a tissue-dependent manner and tissue-independent manner. In …

The bone is an important organ that performs various functions, and the bone marrow inside
the skeleton is composed of a complex intermix of hematopoietic, vascular, and skeletal …

Epigenetic modifications are heritable changes in gene expression without changes in DNA
sequence. DNA methylation has been implicated in the control of several cellular processes …

Abstract DNA 甲基化和去甲基化是表观遗传学的重要机制之一, 在细胞分化, 增殖,
衰老等方面具有重要的调控作用. 干细胞在成骨分化过程中成骨特异性基因发生去甲基化进而 …

Bone marrow mesenchymal stromal cells (BMSCs) are multipotent cells able to self-renew
and differentiate, depending on the microenvironment, into adipocytes and osteoblasts …