The adaptive immune system is able to detect and destroy cells that are malignantly
transformed or infected by intracellular pathogens. Specific immune responses against …

Major histocompatibility complex class I (MHC I) molecules present peptides on the surface
of most nucleated cells and allow the immune system to detect and eliminate infected or …

Recognition of foreign and dysregulated antigens by the cellular innate and adaptive
immune systems is in large part dependent on the cell surface display of peptide/MHC …

Adaptive immunity is shaped by a selection of peptides presented on major
histocompatibility complex class I (MHC I) molecules. The chaperones Tapasin (Tsn) and …

Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …

Recognition and elimination of virally or malignantly transformed cells are pivotal tasks of
the adaptive immune system. For efficient immune detection, snapshots of the cellular …

Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent
on the identification of cell surface MHC molecules bearing peptides generated from either …

Peptides presented on MHC I molecules allow the immune system to detect diseased cells.
The displayed peptides typically stem from proteasomal degradation of cytoplasmic proteins …

Peptide loading of MHC-I molecules plays a critical role in the T cell response to infections
and tumors as well as to interactions with inhibitory receptors on natural killer (NK) cells. To …

Major histocompatibility complex class I (MHC I) proteins protect the host from intracellular
pathogens and cellular abnormalities through the binding of peptide fragments derived …