A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

Modifications of neuronal circuits allow the brain to adapt and change with experience. This
plasticity manifests during development and throughout life, and can be remarkably long …

Homeostatic scaling allows neurons to maintain stable activity patterns by globally altering
their synaptic strength in response to changing activity levels. Suppression of activity by the …

Neuronal plasticity is an important feature of the developing brain and requires neuronal
circuits to reconfigure their functional connectivity depending upon activity patterns. To …

Poised for relay or storage of synaptic information, the postsynaptic neuron must assimilate
a variety of incoming synaptic signals and then integrate these into short-and long-term …

Learning and memory are basic functions of the brain that allowed human evolution. It is
well accepted that during learning and memory formation the dynamic establishment of new …

Highlights•IEG promoters driving reporters allow targeting of recently active neurons in
vivo.•Fos-tTA mice drive effectors in previously active neurons for several days.•IEG …

Sensory experience and the resulting synaptic activity within the brain are critical for the
proper development of neural circuits. Experience-driven synaptic activity causes membrane …

Activity-driven transcription is a key event associated with long-lasting forms of neuronal
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …

Synaptic activity regulates the expression of a set of neuronal gene products that are
important for neuronal survival and differentiation, synaptogenesis and, ultimately, complex …