[HTML][HTML] Effect of n-3 polyunsaturated fatty acids on ischemic heart disease and cardiometabolic risk factors: a two-sample Mendelian randomization study

B Xu, Z Xu, D Xu, X Tan - BMC Cardiovascular Disorders, 2021 - Springer
Background The cardioprotective ability of n-3 polyunsaturated fatty acids (PUFAs) is
controversial. Most studies suggest a specific role for PUFAs in cardioprotection from …

[HTML][HTML] Causal effects of serum levels of n-3 or n-6 polyunsaturated fatty acids on coronary artery disease: Mendelian randomization study

S Park, S Lee, Y Kim, Y Lee, MW Kang, K Kim, YC Kim… - Nutrients, 2021 - mdpi.com
We aimed to investigate the causal effects of n-3 and n-6 polyunsaturated fatty acids
(PUFAs) on the risk of coronary artery disease (CAD) through Mendelian randomization …

[HTML][HTML] Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

JV Zhao, CM Schooling - BMC medicine, 2019 - Springer
Background The role of n-6 polyunsaturated fatty acids (PUFAs) in ischemic heart disease
(IHD) is controversial, and dietary guidelines vary. Observationally, lower saturated fat intake …

Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies

Y Xiao, Y Chen, A Pietzner, U Elbelt, Z Fan… - Nutrients, 2024 - mdpi.com
Long-chain n-3 polyunsaturated fatty acid (PUFA) supplementation has shown potential
benefits in the prevention of coronary heart disease (CHD); however, the impact of omega-3 …

[HTML][HTML] Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association …

MC Borges, PC Haycock, J Zheng, G Hemani… - BMC medicine, 2022 - Springer
Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA),
there is still substantial controversy and uncertainty on the evidence linking PUFA to …

[HTML][HTML] Associations of polyunsaturated fatty acids with cardiovascular disease and mortality: a study of NHANES database in 2003–2018

N Zhong, P Han, Y Wang, C Zheng - BMC Endocrine Disorders, 2023 - Springer
Background This study was to explore the association between dietary polyunsaturated fatty
acids (PUFAs) consumption and cardiovascular diseases (CVDs), all-cause mortality, and …

[HTML][HTML] Impact of omega-6 fatty acids on cardiovascular outcomes: A review

S Khandelwal, L Kelly, R Malik… - Journal of preventive …, 2013 - ncbi.nlm.nih.gov
Poly unsaturated fatty acids (PUFAs) have usually been associated with beneficial health
effects on early life and later life disease such as cardiovascular diseases (CVD). Emerging …

Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study

JHY Wu, RN Lemaitre, IB King, X Song, BM Psaty… - Circulation, 2014 - Am Heart Assoc
Background—Although omega-6 polyunsaturated fatty acids (n-6 PUFA) have been
recommended to reduce coronary heart disease (CHD), controversy remains about benefits …

n-3 PUFAs and cardiovascular disease prevention

A Manerba, E Vizzardi, M Metra, L Dei Cas - Future Cardiology, 2010 - Taylor & Francis
Today, there are several observational and experimental studies, especially clinical
randomized trials, that have proven the beneficial effects of n-3 polyunsaturated fatty acids …

Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men

D Mozaffarian, A Ascherio, FB Hu, MJ Stampfer… - Circulation, 2005 - Am Heart Assoc
Background—Consumption of polyunsaturated fatty acids (PUFAs) may reduce coronary
heart disease (CHD) risk, but n-6 PUFAs may compete with n-3 PUFA metabolism and …