Apoptosis is the major mode of programmed cell death, which conduces to maintain tissue
homeostasis, clearance of abnormal cells and development of organisms. Over the past two …

Escape from apoptosis is often a hallmark of cancer cells, and is associated to
chemotherapy resistance or tumor relapse. Proteins from the Bcl-2 family are the key …

Apoptosis (or programmed cell death) is a genetically controlled “cell suicide” pathway
which plays an essential role in deleting excess, unwanted or damaged cells during …

Apoptosis, also known as programmed cell death, contributes to cellular homeostasis,
normal development and clearance of abnormal cells [1]. Dysregulation of apoptotic …

Inhibiting apoptosis is widely accepted as a necessary step in the transition from normal to
cancer cells, and most cancer therapies exert their effects by indirectly reversing this …

Introduction: The B-cell lymphoma-2 (Bcl-2) family of proteins is central to the regulation of
apoptosis, which is vital for proper tissue development and cellular homeostasis. Anti …

Members of the BCL-2 family of proteins regulate and execute many cell intrinsic apoptosis
pathways, including those arising from dysregulated expression of cellular oncogenes …

Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the
interaction within this family dictates whether a cell survives or dies. The dysregulation of the …

Resistance to cell death represents one of the hallmarks of cancer. Various genetic and
epigenetic changes in malignant cells afford cytoprotection in the face of genomic instability …

The induction of apoptosis in tumor cells represents a promising approach to the treatment
of cancer. Accordingly, compounds that interact with the Bcl-2 family of proteins, which are …