Despite the availability of a range of treatment options and management guidelines, a high
proportion of adults with asthma remain uncontrolled. The challenge of managing …

OBJECTIVE: This meta-analysis was performed to evaluate the efficacy and safety of the
addition of tiotropium to standard treatment regimens for inadequately controlled asthma …

Tiotropium bromide is a long-acting muscarinic antagonist (LAMA) and is the only LAMA
licensed for management for patients'≥ 6 years old with severe asthma who have …

Severe asthma is associated with substantial morbidity and mortality. Therapies must be
maximized to gain control of a patient's severe asthma; however, avoiding overtreatment is …

Introduction: Asthma is a prevalent disease affecting millions of individuals. Despite
receiving guideline therapy with inhaled corticosteroids (ICS) with or without a long-acting …

Purpose Chronic obstructive pulmonary disease (COPD) and asthma are leading causes of
morbidity and mortality. This narrative review provides an appraisal of the pharmacological …

Despite current therapeutic approaches asthma remains uncontrolled in a significant
proportion of patients. Short-acting anticholinergic bronchodilators have a very long history …

Given the high proportion of patients with asthma who remain uncontrolled despite controller
treatment, there remains a need for the development of more effective treatment options with …

Background Studies in adults and adolescents have demonstrated that tiotropium is
efficacious as an add-on therapy to inhaled corticosteroids (ICSs) with or without other …

Asthma is one of the most common chronic diseases in children, with a high proportion of
patients demonstrating poor control despite the availability of disease management …