Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on …
AL Pehrson, T Jeyarajah, C Sanchez - CNS spectrums, 2016 - cambridge.org
Previous work from this laboratory hypothesized that the multimodal antidepressant
vortioxetine enhances cognitive function through a complex mechanism, using serotonergic …
vortioxetine enhances cognitive function through a complex mechanism, using serotonergic …
Serotonergic regulation of prefrontal cortical circuitries involved in cognitive processing: a review of individual 5-HT receptor mechanisms and concerted effects of 5 …
SC Leiser, Y Li, AL Pehrson, E Dale… - ACS chemical …, 2015 - ACS Publications
It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …
Impact of vortioxetine on synaptic integration in prefrontal-subcortical circuits: comparisons with escitalopram
S Chakroborty, TR Geisbush, E Dale… - Frontiers in …, 2017 - frontiersin.org
Prefrontal-subcortical circuits support executive functions which often become dysfunctional
in psychiatric disorders. Vortioxetine is a multimodal antidepressant that is currently used in …
in psychiatric disorders. Vortioxetine is a multimodal antidepressant that is currently used in …
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter …
SM Stahl - CNS spectrums, 2015 - cambridge.org
Vortioxetine is an antidepressant that targets multiple pharmacologic modes of action at
sites—or nodes—where serotonergic neurons connect to various brain circuits. These …
sites—or nodes—where serotonergic neurons connect to various brain circuits. These …
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): modifying serotonin's downstream effects on glutamate and GABA …
SM Stahl - CNS spectrums, 2015 - cambridge.org
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA):
modifying serotoninTs downstream effe Page 1 Modes and nodes explain the mechanism of …
modifying serotoninTs downstream effe Page 1 Modes and nodes explain the mechanism of …
Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus
E Dale, H Zhang, SC Leiser, Y Xiao… - Journal of …, 2014 - journals.sagepub.com
Vortioxetine, a novel antidepressant with multimodal action, is a serotonin (5-HT) 3, 5-HT7
and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor …
and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor …
The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat …
E Dale, M Grunnet, AL Pehrson, K Frederiksen… - Brain research, 2018 - Elsevier
The multimodal antidepressant vortioxetine is thought to mediate its pharmacological effects
via 5-HT 1A receptor agonism, 5-HT 1B receptor partial agonism, 5-HT 1D, 5-HT 3, 5-HT 7 …
via 5-HT 1A receptor agonism, 5-HT 1B receptor partial agonism, 5-HT 1D, 5-HT 3, 5-HT 7 …
Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT1A Receptor with 5-HT3 Receptor Inhibition in Rats
M Okada, R Okubo, K Fukuyama - International journal of molecular …, 2019 - mdpi.com
Vortioxetine is a novel, multimodal antidepressant with unique targets, including the
inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5 …
inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5 …
[HTML][HTML] Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: focus on glutamatergic and GABAergic neurotransmission
The antidepressant vortioxetine is a 5-HT 3-R, 5-HT 7-R and 5-HT 1D-R antagonist, 5-HT 1B-
R partial agonist, 5-HT 1A-R agonist, and serotonin (5-HT) transporter (SERT) inhibitor …
R partial agonist, 5-HT 1A-R agonist, and serotonin (5-HT) transporter (SERT) inhibitor …
Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): blocking 5HT3 receptors enhances release of serotonin …
SM Stahl - CNS spectrums, 2015 - cambridge.org
Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets
where serotonin neurons connect with other neurons. 5HT3 receptor antagonism is one of …
where serotonin neurons connect with other neurons. 5HT3 receptor antagonism is one of …