Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules
H Zhang, Y Zhang, C Zhang, H Yu, Y Ma, Z Li, N Shi - Pharmaceutics, 2023 - mdpi.com
Peptides and proteins, two important classes of biomacromolecules, play important roles in
the biopharmaceuticals field. As compared with traditional drugs based on small molecules …
the biopharmaceuticals field. As compared with traditional drugs based on small molecules …
Cell-penetrating peptides: from basic research to clinics
G Guidotti, L Brambilla, D Rossi - Trends in pharmacological sciences, 2017 - cell.com
The presence of cell and tissue barriers together with the low biomembrane permeability of
various therapeutics often hampers systemic drug distribution; thus, most of the available …
various therapeutics often hampers systemic drug distribution; thus, most of the available …
An opportunistic route to success: Towards a change of paradigm to fully exploit the potential of cell-penetrating peptides
EC Camps, R Brock - Bioorganic & Medicinal Chemistry, 2018 - Elsevier
About 25 years ago it was demonstrated that certain peptides possess the ability to cross the
plasma membrane. This led to the development of cell-penetrating peptides (CPPs) as …
plasma membrane. This led to the development of cell-penetrating peptides (CPPs) as …
Cell-penetrating peptide-based delivery of macromolecular drugs: development, strategies, and progress
Z Sun, J Huang, Z Fishelson, C Wang, S Zhang - Biomedicines, 2023 - mdpi.com
Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …
extensively studied due to their excellent delivery performance. Compared with other …
[HTML][HTML] Cell-penetrating peptides as noninvasive transmembrane vectors for the development of novel multifunctional drug-delivery systems
D Zhang, J Wang, D Xu - Journal of Controlled Release, 2016 - Elsevier
Unique characteristics, such as nontoxicity and rapid cellular internalization, allow the cell-
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides
SH Nam, J Park, H Koo - Archives of Pharmacal Research, 2023 - Springer
Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …
Cell-penetrating peptides (CPPs) as therapeutic and diagnostic agents for cancer
RA Bottens, T Yamada - Cancers, 2022 - mdpi.com
Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …
In vivo biodistribution and efficacy of peptide mediated delivery
To transverse the plasma membrane and gain access to the cellular interior is one of the
major obstacles for many novel pharmaceutical molecules. Since the late 1990s, cell …
major obstacles for many novel pharmaceutical molecules. Since the late 1990s, cell …
Applications and challenges for use of cell-penetrating peptides as delivery vectors for peptide and protein cargos
The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …
Cell-penetrating peptides: A challenge for drug delivery
S Aroui, A Kenani - Cheminform. Its Appl, 2020 - books.google.com
Cell-penetrating peptide (CPP) is a term that describes relatively short amphipathic and
cationic peptides (7–30 amino acid residues) with rapid translocation across the cell …
cationic peptides (7–30 amino acid residues) with rapid translocation across the cell …