Background Despite a growing number of prescriptions for antidepressants (over 70 million
in 2018), there is uncertainty about when people with depression might benefit from …

Background Depressive symptoms are usually managed within primary care and
antidepressant medication constitutes the first-line treatment. It remains unclear at present …

Purpose Antidepressants are a first-line treatment for depression, yet many patients do not
respond. There is a need to understand which patients have greater treatment response but …

Background Depression is usually managed in primary care, but most antidepressant trials
are of patients from secondary care mental health services, with eligibility criteria based on …

Introduction Clinical guidelines recommend antidepressants as the first line of treatment for
adults with moderate-to-severe depression. Randomised trials provide the best evidence on …

This paper reports the results of two studies of depressed patients, evaluating the efficacy
and toleration of the selective serotonin reuptake inhibitor (SSRI) sertraline in a general …

Background: In light of emerging evidence questioning the safety of antidepressants, it is
timely to investigate the appropriateness of antidepressant prescribing. This study estimated …

Background: New medications that enter the marketplace have been tested almost
exclusively in controlled clinical trials conducted in specialty research settings. There is …

BackgroundAntidepressant prescribing is widespread. Nonetheless, response to
antidepressants is variable. If it was possible to predict response to medication and thus …

ABSTRACT INTRODUCTION Evidence for the effectiveness of drug treatment for depression
in primary care settings remains limited, with little information on newer antidepressant …