How pragmatic or explanatory is the randomized, controlled trial? The application and enhancement of the PRECIS tool to the evaluation of a smoking cessation trial
P Selby, G Brosky, PI Oh, V Raymond… - BMC medical research …, 2012 - Springer
Background Numerous explanatory randomized trials support the efficacy of chronic disease
interventions, including smoking cessation treatments. However, there is often inadequate …
interventions, including smoking cessation treatments. However, there is often inadequate …
A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers
KE Thorpe, M Zwarenstein, AD Oxman… - Journal of clinical …, 2009 - Elsevier
OBJECTIVE: To propose a tool to assist trialists in making design decisions that are
consistent with their trial's stated purpose. STUDY DESIGN AND SETTING: Randomized …
consistent with their trial's stated purpose. STUDY DESIGN AND SETTING: Randomized …
Comments, Suggestions and Criticisms of the PRECIS-2 Design Tool: A Citation Analysis
Introduction The Pragmatic Explanatory Continuum Indicator Summary (PRECIS) tool,
initially published in 2009 and revised in 2015, was created to assist trialists to align their …
initially published in 2009 and revised in 2015, was created to assist trialists to align their …
The PRECIS-2 tool has good interrater reliability and modest discriminant validity
Abstract Objectives PRagmatic Explanatory Continuum Indicator Summary (PRECIS)-2 is a
tool that could improve design insight for trialists. Our aim was to validate the PRECIS-2 tool …
tool that could improve design insight for trialists. Our aim was to validate the PRECIS-2 tool …
CHARTing a path to pragmatic tobacco treatment research
Introduction It is important to consider the degree to which studies are explanatory versus
pragmatic to understand the implications of their findings for patients, healthcare …
pragmatic to understand the implications of their findings for patients, healthcare …
Making clinical trials more relevant: improving and validating the PRECIS tool for matching trial design decisions to trial purpose
Background If you want to know which of two or more healthcare interventions is most
effective, the randomised controlled trial is the design of choice. Randomisation, however …
effective, the randomised controlled trial is the design of choice. Randomisation, however …
Framing the conversation: use of PRECIS-2 ratings to advance understanding of pragmatic trial design domains
PD Lipman, K Loudon, L Dluzak, R Moloney… - Trials, 2017 - Springer
Background There continues to be debate about what constitutes a pragmatic trial and how
it is distinguished from more traditional explanatory trials. The NIH Pragmatic Trials …
it is distinguished from more traditional explanatory trials. The NIH Pragmatic Trials …
Pragmatic trial design elements showed a different impact on trial interpretation and feasibility than explanatory elements
JB Nieuwenhuis, E Irving, KO Rengerink… - Journal of Clinical …, 2016 - Elsevier
Objectives To illustrate how pragmatic trial design elements or inserting explanatory trial
elements in pragmatic trials affect validity, generalizability, precision, and operational …
elements in pragmatic trials affect validity, generalizability, precision, and operational …
Pragmatic vs. explanatory: an adaptation of the PRECIS tool helps to judge the applicability of systematic reviews for daily practice
T Koppenaal, J Linmans, JA Knottnerus… - Journal of clinical …, 2011 - Elsevier
OBJECTIVE: The Pragmatic–Explanatory Continuum Indicator Summary (PRECIS) tool was
designed to classify randomized clinical trials (RCT) as being more pragmatic or …
designed to classify randomized clinical trials (RCT) as being more pragmatic or …
The role of pragmatism in explaining heterogeneity in meta-analyses of randomised trials: a protocol for a cross-sectional methodological review
Introduction There has been increasing interest in pragmatic trials methodology. As a result,
tools such as the Pragmatic-Explanatory Continuum Indicator Summary-2 (PRECIS-2) are …
tools such as the Pragmatic-Explanatory Continuum Indicator Summary-2 (PRECIS-2) are …