Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

H Zhao, T Ming, S Tang, S Ren, H Yang, M Liu, Q Tao… - Molecular cancer, 2022 - Springer
Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Wnt/β-catenin signaling pathway in the development and progression of colorectal cancer

K He, WJ Gan - Cancer Management and Research, 2023 - Taylor & Francis
The Wnt/β-catenin signaling pathway is a growth control pathway involved in various
biological processes as well as the development and progression of cancer. Colorectal …

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer

Y Ji, J Lv, D Sun, Y Huang - … journal of molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress
has been made in recent years, CRC survival remains unsatisfactory due to high metastasis …

Advances of Wnt signalling pathway in colorectal cancer

Y Zhu, X Li - Cells, 2023 - mdpi.com
Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a
high mortality rate despite the decreasing incidence and new diagnostic and therapeutic …

[HTML][HTML] Wnt2 complements Wnt/β-catenin signaling in colorectal cancer

YS Jung, S Jun, SH Lee, A Sharma, JI Park - Oncotarget, 2015 - ncbi.nlm.nih.gov
Wnt2 is implicated in various human cancers. However, it remains unknown how Wnt2 is
upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is …

Emerging roles of Wnt ligands in human colorectal cancer

X Nie, H Liu, L Liu, YD Wang, WD Chen - Frontiers in oncology, 2020 - frontiersin.org
Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …

Wnt signaling as a therapeutic target for cancer

A Herbst, FT Kolligs - Target Discovery and Validation Reviews and …, 2007 - Springer
The Wnt/β-catenin signaling pathway is tightly regulated and has important functions in
development, tissue homeostasis, and regeneration. Deregulation of Wnt/β-catenin …

[HTML][HTML] Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

X Cheng, X Xu, D Chen, F Zhao, W Wang - Biomedicine & …, 2019 - Elsevier
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer

J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Therapeutic potential of targeting Wnt/β‐catenin pathway in treatment of colorectal cancer: rational and progress

A Bahrami, F Amerizadeh… - Journal of cellular …, 2017 - Wiley Online Library
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor
types, including colon cancer. Aberrant activation of this pathway is associated with cell …