Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
H Zhao, T Ming, S Tang, S Ren, H Yang, M Liu, Q Tao… - Molecular cancer, 2022 - Springer
Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …
that functions most commonly in embryonic development and cancer, but is also involved in …
Wnt/β-catenin signaling pathway in the development and progression of colorectal cancer
K He, WJ Gan - Cancer Management and Research, 2023 - Taylor & Francis
The Wnt/β-catenin signaling pathway is a growth control pathway involved in various
biological processes as well as the development and progression of cancer. Colorectal …
biological processes as well as the development and progression of cancer. Colorectal …
Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer
Y Ji, J Lv, D Sun, Y Huang - … journal of molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress
has been made in recent years, CRC survival remains unsatisfactory due to high metastasis …
has been made in recent years, CRC survival remains unsatisfactory due to high metastasis …
Advances of Wnt signalling pathway in colorectal cancer
Y Zhu, X Li - Cells, 2023 - mdpi.com
Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a
high mortality rate despite the decreasing incidence and new diagnostic and therapeutic …
high mortality rate despite the decreasing incidence and new diagnostic and therapeutic …
[HTML][HTML] Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
Wnt2 is implicated in various human cancers. However, it remains unknown how Wnt2 is
upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is …
upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is …
Emerging roles of Wnt ligands in human colorectal cancer
X Nie, H Liu, L Liu, YD Wang, WD Chen - Frontiers in oncology, 2020 - frontiersin.org
Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …
Wnt signaling as a therapeutic target for cancer
A Herbst, FT Kolligs - Target Discovery and Validation Reviews and …, 2007 - Springer
The Wnt/β-catenin signaling pathway is tightly regulated and has important functions in
development, tissue homeostasis, and regeneration. Deregulation of Wnt/β-catenin …
development, tissue homeostasis, and regeneration. Deregulation of Wnt/β-catenin …
[HTML][HTML] Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer
X Cheng, X Xu, D Chen, F Zhao, W Wang - Biomedicine & …, 2019 - Elsevier
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …
Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer
J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …
Therapeutic potential of targeting Wnt/β‐catenin pathway in treatment of colorectal cancer: rational and progress
A Bahrami, F Amerizadeh… - Journal of cellular …, 2017 - Wiley Online Library
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor
types, including colon cancer. Aberrant activation of this pathway is associated with cell …
types, including colon cancer. Aberrant activation of this pathway is associated with cell …