Optimization protocol of fixation method for trophoblast retrieval from the cervix (TRIC): a preliminary study

MJ Lee, SH Kim, SH Shim, HY Jang, HJ Park, DH Cha - Diagnostics, 2020 - mdpi.com
Extravillous trophoblast cells (EVTs) secreted by the uterine cavity may help overcome
limitations associated with prenatal testing currently in use. EVTs are isolated using a …

Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies

G Moser, S Drewlo, B Huppertz… - Human Reproduction …, 2018 - academic.oup.com
BACKGROUND Early during human development, the trophoblast lineage differentiates to
commence placentation. Where the placenta contacts the uterine decidua, extravillous …

Advanced strategy of trophoblasts retrieval and isolation from the cervix (TRIC): comparison of two HLA-G antibodies for immunomagnetic isolation of trophoblasts

K Hong, HY Jang, SH Shim, HY Cho… - Journal of Personalized …, 2022 - mdpi.com
Trophoblasts retrieval and isolation from the cervix (TRIC) is a non-invasive method which
enables analysis of fetal genetic information from the extravillous trophoblast cells (EVTs) …

Retrieval of trophoblast cells from the cervical canal for prediction of abnormal pregnancy: a pilot study

AN Imudia, Y Suzuki, BA Kilburn, FD Yelian… - Human …, 2009 - academic.oup.com
BACKGROUND Fetal cells are shed from the regressing chorionic villi and it is possible to
retrieve extravillous cytotrophoblast cells by transcervical sampling. The abundance of …

A rapid method for label-free enrichment of rare trophoblast cells from cervical samples

CM Bailey-Hytholt, S Sayeed, M Kraus, R Joseph… - Scientific Reports, 2019 - nature.com
Extravillous trophoblasts (EVTs) have the potential to provide the entire fetal genome for
prenatal testing. Previous studies have demonstrated the presence of EVTs in the cervical …

[HTML][HTML] Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC)

R Fritz, HR Kohan-Ghadr, JM Bolnick, AD Bolnick… - Fertility and sterility, 2015 - Elsevier
Objective To examine the expression pattern of biomarker proteins in extravillous
trophoblast (EVT) cells obtained noninvasively by trophoblast retrieval and isolation from the …

[HTML][HTML] Trophoblast retrieval and isolation from the cervix (TRIC) for noninvasive prenatal screening at 5 to 20 weeks of gestation

JM Bolnick, BA Kilburn, S Bajpayee, N Reddy… - Fertility and sterility, 2014 - Elsevier
Objective To use trophoblast cells accumulating in the endocervical canal at the beginning
of pregnancy for noninvasive prenatal testing. Design Prospective, double-blinded test for …

A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC)

K Hong, HJ Park, HY Jang, SH Shim, Y Jang, SH Kim… - Diagnostics, 2023 - mdpi.com
As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal
chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and …

[HTML][HTML] Quo vadis, trophoblast? Exploring the new ways of an old cell lineage

S Drewlo, DR Armant - Placenta, 2017 - Elsevier
Trophoblast cells are the first embryonic lineage to differentiate during human development,
and are needed to sustain fetal life through their role in constructing a placenta. As the fetus …

Noninvasive isolation of transcervical trophoblast cells for fetal identification

Y Gao, L Ruan, L Cao, G Lu, Q Hong… - Journal of Obstetrics …, 2022 - Wiley Online Library
Objective To identify trophoblastic cells retrieved from the cervix at a gestational age (GA) of
5–9 weeks by a noninvasive modality in fetuses. Method Transcervical cells (TCCs) were …