Various pathophysiological mechanisms have been implicated in hypertension, but those
resulting in vascular dysfunction and remodeling are critical and may help to identify critical …

Matrix metalloproteinases (MMPs) are important extracellular enzymes involved in many
physiological and pathological processes. Changes in the activity and concentration of …

A group of proteases, the matrix metalloproteinases (MMPs) are well known for their
capacity to degrade extracellular matrix (ECM) proteins. Particularly MMP-2 and MMP-9 …

Hypertension is associated with vascular remodeling characterized by rearrangement of
extracellular matrix proteins. To evaluate how matrix metalloproteinase (MMP)-9 contributes …

Hypertension is associated with well known structural and functional alterations in both
resistance and conduit arteries, which may be the result from long-lasting high blood …

Hypertension is associated with cardiovascular remodeling. Given that impaired redox state
activates matrix metalloproteinase (MMP)− 2 and promotes vascular remodeling, we …

Inward eutrophic remodeling is a common structural change found in small resistance
arteries that has been associated with an increased risk for life threatening cardiovascular …

Vascular remodeling, defined as any enduring change in the size and/or composition of an
adult blood vessel, allows adaptation and repair. On the other hand, inappropriate …

The renal vasculature is highly susceptible to deleterious structural and functional changes
induced by high blood pressure. In particular, hypertension is associated with an increase in …

Since the first successful launch of the Veterans Administration (VA) cooperative studies in
the late 1960s, the increasing access to blood pressure lowering medications has …