Highly oxidized low-density lipoprotein does not facilitate platelet aggregation

A Miyazaki, T Uehara, Y Usami… - Journal of …, 2020 - journals.sagepub.com
Objective This study aimed to examine whether oxidized low-density lipoprotein (oxLDL)
facilitates platelet aggregation, which is one cause for development of cardiovascular …

Inhibitory mechanisms of low concentrations of oxidized low-density lipoprotein on platelet aggregation

DS Chou, CH Chan, G Hsiao, MY Shen, YJ Tsai… - Journal of biomedical …, 2006 - Springer
The intracellular mechanisms underlying oxidized low-density lipoprotein (oxLDL)-signaling
pathways in platelets are not yet completely understood. Therefore, the aim of this study was …

Binding of oxidized low-density lipoprotein on circulating platelets is increased in patients with acute coronary syndromes and induces platelet adhesion to vascular …

K Stellos, R Sauter, M Fahrleitner, J Grimm… - … , and vascular biology, 2012 - Am Heart Assoc
Objective—Hyperlipidemia is associated with platelet hyperactivity. In the present study, we
evaluated the binding of oxidized low-density lipoprotein (oxLDL) on the surface of …

Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: An intracellular study

DS Chou, G Hsiao, MY Shen, TH Fong, CH Lin… - Lipids, 2004 - Wiley Online Library
The intracellular mechanisms underlying oxidized low density lipoprotein (oxLDL)‐signaling
pathways in platelets remain obscure and findings have been controversial. Therefore, we …

LDL oxidation by platelets propagates platelet activation via an oxidative stress-mediated mechanism

R Carnevale, S Bartimoccia, C Nocella, S Di Santo… - Atherosclerosis, 2014 - Elsevier
Objectives Platelets generate oxidized LDL (ox-LDL) via NOX2-derived oxidative stress. We
investigated if once generated by activated platelets ox-LDL can propagate platelet …

Platelet activation by oxidatively modified low density lipoproteins

NG Ardlie, ML Selley, LA Simons - Atherosclerosis, 1989 - Elsevier
Interactions between altered lipoproteins and platelets may be important in atherosclerosis
lesion formation and thrombosis. The aims of this study were to compare the effects of …

Oxidized LDL-activated platelets induce vascular inflammation

K Daub, P Seizer, K Stellos, BF Krämer… - … in thrombosis and …, 2010 - thieme-connect.com
Platelets are involved in the initiation of atherosclerosis by adherence to inflamed
endothelium. Monocytes bind to these platelets and transmigrate into the vessel wall …

Native high density lipoproteins (HDL) interfere with platelet activation induced by oxidized low density lipoproteins (OxLDL)

S Badrnya, A Assinger, I Volf - International journal of molecular sciences, 2013 - mdpi.com
Platelets and lipoproteins play a crucial role in atherogenesis, in part by their ability to
modulate inflammation and oxidative stress. While oxidized low density lipoproteins …

Effect of oxidation on the platelet-activating properties of low-density lipoprotein

SJA Korporaal, G Gorter, HJM van Rijn… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Because of the large variation in oxidizing procedures and susceptibility to
oxidation of low-density lipoprotein (LDL) and the lack in quantification of LDL oxidation, the …

Effect of glucose and insulin on oxidized low-density lipoprotein phagocytosis by human monocytes: a pilot study

M Sarigianni, E Bekiari, A Tsapas, K Topouridou… - …, 2011 - journals.sagepub.com
We assessed the effect of glucose and insulin on human monocytes. Monocytes were
isolated from 16 healthy obese and 10 lean healthy participants. Insulin sensitivity was …