Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein

W Siess - Pathophysiology of haemostasis and thrombosis, 2006 - karger.com
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic
mediators that play a crucial role in cardiovascular and inflammatory diseases. Mildly …

Oxidized low-density lipoprotein: a double-edged sword on atherosclerosis

B Yu, S Zhao, X Huang - Medical hypotheses, 2007 - Elsevier
It is well known that atherosclerosis is closely related to lipoprotein metabolism, particularly
to the low density lipoprotein (LDL). LDL becomes atherogenic after undergoing oxidation …

The importance of oxidation or glycosylation of low-density lipoproteins in relation to platelet activation

S Meraji, CE Moore, VO Skinner, KR Bruckdorfer - Platelets, 1992 - Taylor & Francis
Low-density lipoproteins (LDL) are thought to influence directly the sensitivity of platelets,
but this may only be the case when the LDL are modified by oxidation. In diabetes, LDL are …

Platelet secretory products increase low density lipoprotein oxidation, enhance its uptake by macrophages, and reduce its fluidity.

M Aviram, G Dankner, JG Brook - Arteriosclerosis: An Official …, 1990 - Am Heart Assoc
Oxidized low density lipoprotein (Ox-LDL) is considered to be involved in the atherogenic
process. Factors influencing the formation of Ox-LDL are thus of importance. Oxidation of …

Enhancement of platelet aggregation by low-density lipoproteins from IDDM patients

J Watanabe, HJ Wohltmann, RL Klein, JA Colwell… - Diabetes, 1988 - Am Diabetes Assoc
Low-density lipoprotein (LDL) is known to enhance platelet sensitivity to some aggregating
agents. In this study, we observed that LDL isolated from patients with insulin-dependent …

Differential effects of native and oxidatively modified low-density lipoproteins on platelet function

KM Naseem, AH Goodall, KR Bruckdorfer - Platelets, 1997 - Taylor & Francis
Low-density lipoproteins (LDL) have been various reported to induce platelet aggregation
independently and/or sensitise platelets to other agonists. In these earlier studies the extent …

Adhesion of washed blood platelets in vitro is advanced, accelerated, and enlarged by oxidized low‐density lipoprotein

B Zhao, CH Rickert, TJ Filler, B Liu… - American journal of …, 1995 - Wiley Online Library
In order to study the influence of oxidized low-density lipoprotein (Ox-LDL) on platelet
functional morphology at an early activation stage, washed human blood platelets were …

The effect of oxidized low density lipoproteins on ADP-induced platelet aggregation in plasma

II Vlasova, TV Vakhrusheva, OA Azizova… - Voprosy meditsinskoi …, 1998 - europepmc.org
The investigation of the effect of oxidized lipoproteins on platelet activity is important for the
understanding of the plague formation under atherosclerosis. In the present work, we …

LDL-cholesterol and platelets: insights into their interactions in atherosclerosis

A Gąsecka, S Rogula, Ł Szarpak, KJ Filipiak - Life, 2021 - mdpi.com
Atherosclerosis and its complications, including acute coronary syndromes, are the major
cause of death worldwide. The two most important pathophysiological mechanisms …

In vivo low density lipoprotein oxidation relates to coronary reactivity in young men

OT Raitakari, OP Pitkänen, T Lehtimäki… - Journal of the American …, 1997 - jacc.org
Objectives. This study was undertaken to examine the relation of in vivo low density
lipoprotein (LDL) oxidation and other lipid risk factors to coronary reactivity in normal …