[HTML][HTML] Stacey Finley
A Popel - J Natl Cancer Inst - bioseek.eu
BACKGROUND Vascular endothelial growth factor (VEGF) is known to be a potent promoter
of angiogenesis under both physiological and pathological conditions. Given its role in …
of angiogenesis under both physiological and pathological conditions. Given its role in …
Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions
Background Vascular endothelial growth factor (VEGF) is known to be a potent promoter of
angiogenesis under both physiological and pathological conditions. Given its role in …
angiogenesis under both physiological and pathological conditions. Given its role in …
[HTML][HTML] Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …
Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis, whose effect
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
on cancer growth and development is well characterized. Alternative splicing of VEGF leads …
Mechanistic modeling quantifies the influence of tumor growth kinetics on the response to anti-angiogenic treatment
TD Gaddy, Q Wu, AD Arnheim… - PLoS computational …, 2017 - journals.plos.org
Tumors exploit angiogenesis, the formation of new blood vessels from pre-existing
vasculature, in order to obtain nutrients required for continued growth and proliferation …
vasculature, in order to obtain nutrients required for continued growth and proliferation …
New VEGF model-based biomarker
L Hutchinson - Nature Reviews Clinical Oncology, 2013 - nature.com
This mathematical model is an advance in our understanding of the potential different roles
of VEGF isoforms in the tumour and in the blood circulation. In an accompanying …
of VEGF isoforms in the tumour and in the blood circulation. In an accompanying …
Mechanistic insights into the heterogeneous response to anti‐VEGF treatment in tumors
Vascular endothelial growth factor (VEGF) is a strong promoter of angiogenesis in tumors,
and anti‐VEGF treatment, such as a humanized antibody to VEGF, is clinically used as a …
and anti‐VEGF treatment, such as a humanized antibody to VEGF, is clinically used as a …
Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
Vascular endothelial growth factor (VEGF) is one of the most potent cytokines targeted in
antiangiogenic therapies. Bevacizumab, a recombinant humanized monoclonal antibody to …
antiangiogenic therapies. Bevacizumab, a recombinant humanized monoclonal antibody to …
Simulating therapeutics using multiscale models of the VEGF receptor system in cancer
FM Gabhann, MO Stefanini, AS Popel - Modeling tumor vasculature …, 2012 - Springer
Abstract In recent years, Judah Folkman's vision of anticancer therapeutics based on
inhibiting angiogenesis pathways has begun to be realized. In particular, antibodies …
inhibiting angiogenesis pathways has begun to be realized. In particular, antibodies …
Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies
SD Finley, MO Engel-Stefanini, PI Imoukhuede… - BMC systems …, 2011 - Springer
Background Vascular endothelial growth factor (VEGF) is a potent regulator of
angiogenesis, and its role in cancer biology has been widely studied. Many cancer …
angiogenesis, and its role in cancer biology has been widely studied. Many cancer …