B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct
stages. During early embryonic development, pHSCs migrate into the fetal liver, where they …

Publisher Summary The chapter discusses humoral self-tolerance as the cumulative action
of a series of separate checkpoints placed along the B cell lineage. The strategy of …

The development of B cells from haematopoietic stem cells proceeds along a highly
ordered, yet flexible, pathway. At multiple steps along this pathway, cells are instructed by …

Summary OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON B CELL
SUBSETS IN DISEASE B cells in multiple sclerosis: drivers of disease pathogenesis and …

Abstract Development of mammalian B-lineage cells is characterized by progression
through a series of checkpoints defined primarily by rearrangement and expression of …

In adult mammals, bone marrow pluripotent hematopoietic stem cells generate B lymphoid‐
specified progeny that progress through a series of well‐characterized stages before …

A role for B cells in autoimmune diseases is now clearly established both in mouse models
and humans by successful treatment of multiple sclerosis and rheumatoid arthritis with anti …

B cells have to progress through various checkpoints during their process of development.
The three transcription factors E2A, EBF (early B cell factor) and Pax5 play essential roles in …

B lymphocytes are essential antibody-producing cells of the immune system. During the
development of progenitor B cells to mature B cells that express a membrane-bound …

Humoral immunity depends on efficient activation of B cells and their subsequent
differentiation into antibody-secreting cells (ASCs). The transcription factor NFκB cRel is …