Female breast cancer has become the most commonly occurring cancer worldwide.
Although it has a good prognosis under early diagnosis and appropriate treatment, breast …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

Breast cancer is the most common malignancy in women and a significant cause of
morbidity and mortality. Sub-types of breast cancer defined by the expression of steroid …

Recent studies revealed that E3 ubiquitin ligases play important roles in breast
carcinogenesis. Clinical research studies have found that (epi)-genetic (deletion …

Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

Metastatic disease is the major cause of breast cancer–related death and despite many
advances, current therapies are rarely curative. Tumor cell migration and invasion require …

Background: The ubiquitin-proteasomal degradation pathway plays a critical role in protein
degradation and regulates a wide variety of cellular functions. This highly conserved post …

E3 ubiquitin ligases are a large family of proteins that can be classified into three major
structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C …

Ubiquitination plays many critical roles in protein function and regulation. Consequently,
mutation and aberrant expression of E3 ubiquitin ligases can drive cancer progression …