Immunofluorescence identifies distinct subsets of endothelial cells in the human liver

O Strauss, A Phillips, K Ruggiero, A Bartlett… - Scientific reports, 2017 - nature.com
As well as systemic vascular endothelial cells, the liver has specialised sinusoidal
endothelial cells (LSEC). LSEC dysfunction has been documented in many diseased states …

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

J Poisson, S Lemoinne, C Boulanger, F Durand… - Journal of …, 2017 - Elsevier
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic …

The evolving role of liver sinusoidal endothelial cells in liver health and disease

MJ McConnell, E Kostallari, SH Ibrahim, Y Iwakiri - Hepatology, 2023 - journals.lww.com
LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

[HTML][HTML] Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo

PF Lalor, WK Lai, SM Curbishley, S Shetty… - World journal of …, 2006 - ncbi.nlm.nih.gov
The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial
cells (HSEC), which is one of the first hepatic cell populations to come into contact with …

[PDF][PDF] Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

S March, EE Hui, GH Underhill, S Khetani… - …, 2009 - Wiley Online Library
Liver sinusoidal endothelial cells (LSECs) differ, both structurally and functionally, from
endothelial cells (ECs) lining blood vessels of other tissues. For example, in contrast to other …

The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver

AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Liver sinusoidal endothelial cell: an update

LD DeLeve, AC Maretti-Mira - Seminars in liver disease, 2017 - thieme-connect.com
This update focuses on two main topics. First, recent developments in our understanding of
liver sinusoidal endothelial cell (LSEC) function will be reviewed, specifically elimination of …

Critical role of LSEC in post-hepatectomy liver regeneration and failure

M De Rudder, A Dili, P Stärkel, IA Leclercq - International journal of …, 2021 - mdpi.com
Liver sinusoids are lined by liver sinusoidal endothelial cells (LSEC), which represent
approximately 15 to 20% of the liver cells, but only 3% of the total liver volume. LSEC have …

The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity

K Elvevold, B Smedsrød… - American Journal of …, 2008 - journals.physiology.org
A look through the literature on liver sinusoidal endothelial cells (LSECs) reveals that there
are several conflicts among different authors of what this cell type is and does. Major …