Neuroinflammation plays an important role in the pathogenesis of ocular surface disease,
including dry eye disease (DED), but little is known about the contribution of substance P …

Substance P (SP) is a tachykinin neuropeptide, implicated in the pathogenesis of various
inflammatory conditions and a critical mediator in pain transmission. Recently, the role of SP …

Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune
systems. SP is predominantly released by neurons and exerts its biological and …

Background The conjunctiva contains a specialized population of lymphocytes that reside in
the epithelium, named intraepithelial lymphocytes (IEL). Methodology/Principal Findings …

Substance P neuropeptide and its receptor, neurokinin-1 receptor (NK1R), are reported to
present on the ocular surface. In this study, mice lacking functional NK1R exhibited an …

We evaluated the changes in substance P (SP)-expressing trigeminal neurons (TNs)
innervating the cornea following ocular surface inflammation. Ocular surface inflammation …

Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye
disease (DED). Increasing evidence indicated that purinergic A1, A2A, A3, P2X4, P2X7 …

Dry eye disease (DED) features the inflammatory response of the ocular surface. Pro-
inflammatory T helper 17 (Th17) cells are important for the pathogenesis of DED. In the …

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-
3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study …

Dry eye disease (DED) is recognized as a chronic inflammatory condition with an increase
in tear osmolarity and loss of tear film integrity. DED is often accompanied by adverse ocular …