[HTML][HTML] Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury

PK Dash, J Zhao, G Hergenroeder, AN Moore - Neurotherapeutics, 2010 - Elsevier
Traumatic brain injury (TBI) remains a serious health concern, and TBI is one of the leading
causes of death and disability, especially among young adults. Although preventive …

Fluid biomarkers of traumatic brain injury and intended context of use

T Bogoslovsky, J Gill, A Jeromin, C Davis… - Diagnostics, 2016 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of death and disability around the
world. The lack of validated biomarkers for TBI is a major impediment to developing effective …

Biomarkers for the clinical differential diagnosis in traumatic brain injury—a systematic review

S Yokobori, K Hosein, S Burks, I Sharma… - CNS neuroscience & …, 2013 - Wiley Online Library
Rapid triage and decision‐making in the treatment of traumatic brain injury (TBI) present
challenging dilemma in “resource poor” environments such as the battlefield and developing …

The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage

S Mondello, K Schmid, RP Berger… - Medicinal research …, 2014 - Wiley Online Library
During the past decade there has been an increasing recognition of the incidence of mild
traumatic brain injury (mTBI) and a better understanding of the subtle neurological and …

Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury: A CENTER-TBI study

DP Whitehouse, M Monteiro, E Czeiter, TV Vyvere… - …, 2022 - thelancet.com
Background We aimed to understand the relationship between serum biomarker
concentration and lesion type and volume found on computed tomography (CT) following all …

Group-based trajectory analysis applications for prognostic biomarker model development in severe TBI: a practical example

C Niyonkuru, AK Wagner, H Ozawa, K Amin… - Journal of …, 2013 - liebertpub.com
Over the last decade, biomarker research has identified potential biomarkers for the
diagnosis, prognosis, and management of traumatic brain injury (TBI). Several cerebrospinal …

Blood-based biomarkers for prediction of intracranial hemorrhage and outcome in patients with moderate or severe traumatic brain injury

TN Anderson, J Hwang, M Munar, L Papa… - Journal of trauma and …, 2020 - journals.lww.com
BACKGROUND Early identification of traumatic intracranial hemorrhage (ICH) has
implications for triage and intervention. Blood-based biomarkers were recently approved by …

Neuroinflammatory biomarkers for traumatic brain injury diagnosis and prognosis: A TRACK-TBI pilot study

JK Yue, FH Kobeissy, S Jain, X Sun… - Neurotrauma …, 2023 - liebertpub.com
The relationship between systemic inflammation and secondary injury in traumatic brain
injury (TBI) is complex. We investigated associations between inflammatory markers and …

Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic …

L Papa, GM Brophy, RD Welch, LM Lewis… - JAMA …, 2016 - jamanetwork.com
Importance Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-
L1) have been widely studied and show promise for clinical usefulness in suspected …

Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood

H Zetterberg, DH Smith, K Blennow - Nature Reviews Neurology, 2013 - nature.com
Mild traumatic brain injury (TBI), which is defined as a head trauma resulting in a brief loss of
consciousness and/or alteration of mental state, is usually benign, but occasionally causes …