Hypertension is characterized by structural and functional changes in blood vessels that
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …

A large body of evidence indicates that patients with essential hypertension are
characterized by endothelial dysfunction mediated by an impaired NO availability secondary …

In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …

Hypertension is a complex condition and is the most common cardiovascular risk factor,
contributing to widespread morbidity and mortality. Approximately 90% of hypertension …

Endothelium-derived nitric oxide is not only a potent vasodilator but also inhibits platelet
aggregation, smooth muscle cell proliferation, monocyte adhesion and adhesion molecule …

Atherosclerosis has complex pathogenesis, which involves at least three serious aspects:
inflammation, lipid metabolism alterations, and endothelial injury. There are no effective …

Pathogenesis of the atherosclerotic process is deemed as multi-factorial, and characterized
by chronic inflammatory response. Although hypertension is known to be one of the most …

The vascular endothelium plays a fundamental role in the basal and dynamic regulation of
the circulation. Thus, it has a crucial role in the pathogenesis of hypertension. A spectrum of …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

Essential hypertension is associated with endothelial dysfunction, which is caused mainly by
the production of oxygen-free radicals that can destroy nitric oxide (NO), and impair its …