Epidemiology of cancer by tobacco products and the significance of TSNA

PC Gupta, PR Murti, RB Bhonsle - Tobacco-Specific N …, 2017 - api.taylorfrancis.com
Globally, oral cancer is one of the ten common cancers. In some parts of the world, including
the Indian subcontinent, oral cancer is a major cancer problem. Tobacco use is the most …

Tobacco‐specific N‐nitrosamines and ARECA‐derived N‐nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans

D Hoffmann, KD Brunnemann… - Journal of Toxicology …, 1994 - Taylor & Francis
Nicotine and the minor tobacco alkaloids give rise to tobacco‐specific N‐nitrosamines
(TSNA) during tobacco processing and during smoking. Chemical‐analytical studies led to …

Unusually high levels of carcinogenic tobacco-specific nitrosamines in Sudan snuff (toombak)

AM Idris, J Nair, H Ohshima, M Friesen, I Brouet… - …, 1991 - academic.oup.com
The aim of these studies was to determine the levels of carcinogenic tobacco specific
nitrosamines (TSNA) in Sudanese oral snuff (toombak) as recent retrospective …

Tobacco‐specific nitrosamines in smokeless tobacco products marketed in India

I Stepanov, SS Hecht, S Ramakrishnan… - … Journal of Cancer, 2005 - Wiley Online Library
Smokeless tobacco products are a known cause of oral cancer in India. Carcinogenic
tobacco‐specific nitrosamines in these products are believed to be at least partially …

Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis

D Hoffmann, A Rivenson, FL Chung… - Critical reviews in …, 1991 - Taylor & Francis
Both smoking and chewing of tobacco deliver chemicals that affect physiological and
behavioral activity. These chemicals induce a dependency on tobacco which has fostered a …

Comparison of tobacco-specific nitrosamine levels in smokeless tobacco products: High levels in products from Bangladesh

S Nasrin, G Chen, CJW Watson, P Lazarus - PLoS One, 2020 - journals.plos.org
Bangladesh exhibits the second highest rate of smokeless tobacco (SLT) product usage in
the world, and this has been associated with the high upper aerodigestive tract cancer …

Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers

DL Ashley, RJ O'Connor, JT Bernert, CH Watson… - … , biomarkers & prevention, 2010 - AACR
Background: Smokers are exposed to significant doses of carcinogens, including tobacco-
specific nitrosamines (TSNA). Previous studies have shown significant global differences in …

Carcinogenic tobacc-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan

AM Idris, J Nair, M Friesen, H Ohshima, I Brouet… - …, 1992 - academic.oup.com
Exposure to tobacco-specific nitrosamines (TSNA) has been measured in the saliva of 12
users of Sudanese oral snuff (toombak). Using GC coupled to thermal energy analysis …

Tobacco-specific nitrosamine exposures in smokers and nonsmokers exposed to cigarette or waterpipe tobacco smoke

G Radwan, SS Hecht, SG Carmella… - Nicotine & Tobacco …, 2012 - academic.oup.com
Introduction: The causal relationship between tobacco smoking and a variety of cancers is
attributable to the carcinogens that smokers inhale, including tobacco-specific nitrosamines …

Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry

I Stepanov, A Knezevich, L Zhang… - Tobacco …, 2012 - tobaccocontrol.bmj.com
Background Modification of tobacco curing methods and other changes in cigarette
manufacturing techniques could substantially reduce the levels of tobacco-specific …