… DNA sequence, is generating increasing interest as a means to help clarify disease pathogenesis
and outcomes. Although genome… cholangitis (PBC) and primary sclerosing cholangitis …

Background Primary sclerosing cholangitis (PSC) is a well‐described risk factor for the
development of cholangiocarcinoma (CCA). Early detection of CCA in these patients is of great …

… Whole genome sequencing (WGS) can provide additional knowledge of mutational spectra
… sequencing. We describe the molecular landscape of CCA using whole-genome sequencing …

… BaCKgRoUND aND aIMS: Lifetime risk of biliary tract cancer (BTC) in primary sclerosing
cholangitis (… We performed tumor DNA sequencing at 42 clinically relevant genetic loci to detect …

… Clinical presentations reflect the underlying sequence of bile duct injury and fibrosis leading
to stricturing, cholestasis, and biliary cirrhosis with progressive liver dysfunction. Primary …

Objective Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often
leading to end-stage liver disease. Its pathogenesis remains largely unknown, although …

… The proportion of total patients with IBD represented by this IBD-associated sclerosing
cholangitis entity has been established at 8.1% 25 , but less than half of these cases are clinically …

… Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease leading to …
As for DNA sequencing-based studies, one study included biopsies from the terminal ileum, …

… Sequencing Full genome sequencing of the CFTR gene was performed using New
Generation Sequencing in 32 patients as previously described [16]. In 29 patients …

… DNA quality. The different processing methods of the brush samples may have influenced
the DNA quality, despite diluting samples with high DNA … DNA concentrations with poor DNA …