Mesenchymal stem cell-derived extracellular vesicles for renal repair

A Aghajani Nargesi, LO Lerman… - Current gene therapy, 2017 - ingentaconnect.com
… mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction
… tested in clinical trials for patients with renal disease. Accumulating evidence indicates that …

Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury

L Zhao, C Hu, P Zhang, H Jiang, J Chen - Journal of Translational …, 2019 - Springer
… of tissues, including renal tissues, finally resulting in renal failure [28]. In the following section,
we will discuss recently updated findings about mitochondrial dysfunction during AKI and …

Treatment with human Wharton's jelly-derived mesenchymal stem cells attenuates sepsis-induced kidney injury, liver injury, and endothelial dysfunction

JM Cóndor, CE Rodrigues… - Stem cells …, 2016 - academic.oup.com
… This study demonstrates that in rats sepsis causes renal, hepatic, and endothelial dysfunction;
increases levels of proinflammatory markers; and induces a Klotho-deficient state. Hu et al…

Relationship between renal dysfunction and electrolyte abnormalities in hematopoietic stem cell transplant patients treated with foscarnet

R Ota, A Hirata - Journal of Chemotherapy, 2021 - Taylor & Francis
… Additionally, we performed a separate analysis on the renal dysfunction and non-renal
dysfunction groups. In the renal dysfunction group, a significant correlation was noted between …

Potential and therapeutic efficacy of cell-based therapy using mesenchymal stem cells for acute/chronic kidney disease

CW Yun, SH Lee - International journal of molecular sciences, 2019 - mdpi.com
… High prevalence of renal dysfunction and its impact on outcome in 118,465 patients
hospitalized with acute decompensated heart failure: A report from the adhere database. J. Card. …

[HTML][HTML] Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease

KW Kim, YJ Shin, BM Kim, S Cui, EJ Ko… - Kidney Research and …, 2021 - ncbi.nlm.nih.gov
renal disease (ESRD). The aim of this study was to generate human induced pluripotent stem
cells… , and appraise the usefulness of hiPSC-ECs as a model to investigate EC dysfunction. …

Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction

WC Shen, YH Chou, HP Huang, JF Sheen… - Stem cell research & …, 2018 - Springer
… in 8–10-week-old mice, followed by left renal I/R injury 2 weeks later. This AKI model was …
and renal pathology. Our data revealed that intravenous infusion of iEPCs 15 min after renal I/…

Mitochondria transfer from mesenchymal stem cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo

N Konari, K Nagaishi, S Kikuchi, M Fujimiya - Scientific reports, 2019 - nature.com
… Mitochondrial dysfunction induced by hyperglycaemia contributes to DN 9 , which results …
reduced ATP production, especially in renal tubular epithelial cells 10,11 . Proximal tubules …

[HTML][HTML] Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes against renal ischemia-reperfusion injury in rats

FA Alzahrani - American journal of translational research, 2019 - ncbi.nlm.nih.gov
… The latter is a devastating renal dysfunction syndrome that has the potential to accelerate
the occurrence of chronic kidney disease (CKD) and further lead to renal failure and high …

Stem cell-derived extracellular vesicles and kidney regeneration

C Grange, R Skovronova, F Marabese, B Bussolati - Cells, 2019 - mdpi.com
… This review focuses on stem cell-derived EVs as a new therapeutic option for renal injury …
The progression of fibrosis is the leading cause of renal dysfunction not only for diabetic …