Cancer associated fibroblasts: the architects of stroma remodeling
A Santi, FG Kugeratski, S Zanivan - Proteomics, 2018 - Wiley Online Library
… stroma contains increased number of fibroblasts, which are pathologically activated and
called cancer associated fibroblasts … , and an ECM profoundly remodeled compared with the …
called cancer associated fibroblasts … , and an ECM profoundly remodeled compared with the …
Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology
NI Nissen, M Karsdal, N Willumsen - … of Experimental & Clinical Cancer …, 2019 - Springer
… Here we give an introduction and overview to the link between tumorigenesis and stromal
… for this altered stromal collagen remodeling, the cancer associated fibroblasts (CAFs), and …
… for this altered stromal collagen remodeling, the cancer associated fibroblasts (CAFs), and …
Cancer-associated fibroblasts mediate cancer progression and remodel the tumouroid stroma
J Pape, T Magdeldin, K Stamati, A Nyga… - … journal of cancer, 2020 - nature.com
… stromal response, cancer-associated fibroblasts (CAFs) are of particular interest. CAFs are
highly differentiated and activated fibroblasts … In the healthy colon tissue, resting fibroblasts …
highly differentiated and activated fibroblasts … In the healthy colon tissue, resting fibroblasts …
Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis
B Erdogan, DJ Webb - Biochemical Society Transactions, 2017 - portlandpress.com
… Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of
carcinomas that emerge in the tumor microenvironment as a result of signals derived from the …
carcinomas that emerge in the tumor microenvironment as a result of signals derived from the …
Metabolic reprogramming of cancer associated fibroblasts: the slavery of stromal fibroblasts
A Avagliano, G Granato, MR Ruocco… - BioMed Research …, 2018 - Wiley Online Library
… CAFs secrete higher levels of H 2 O 2 compared with normal cells, suggesting that
extracellular H 2 O 2 could lead to stroma remodelling. Indeed, treatment of NFs with CAF-…
extracellular H 2 O 2 could lead to stroma remodelling. Indeed, treatment of NFs with CAF-…
The role of cancer-associated fibroblasts in cancer invasion and metastasis
PJ Asif, C Longobardi, M Hahne, JP Medema - Cancers, 2021 - mdpi.com
… The stroma consists of many different cell types, but, in this review, we will focus on … are the
main producers of ECM components and ECM-remodeling enzymes that contribute to stromal …
main producers of ECM components and ECM-remodeling enzymes that contribute to stromal …
Cancer-associated fibroblasts: master tumor microenvironment modifiers
… Cancer-associated fibroblasts (CAFs) are stromal cells in the TME that are integral to …
Similarly, palladin is an actin-binding protein product of CAFs that is indicated in stromal remodeling…
Similarly, palladin is an actin-binding protein product of CAFs that is indicated in stromal remodeling…
Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
… Cancer-associated fibroblasts, the major stromal cells of most solid cancers such as breast
and pancreatic cancers, … of ECM remodeling and in stroma cell (BMDCs, endothelial cells and …
and pancreatic cancers, … of ECM remodeling and in stroma cell (BMDCs, endothelial cells and …
Cancer-associated fibroblast heterogeneity: a factor that cannot be ignored in immune microenvironment remodeling
PY Chen, WF Wei, HZ Wu, LS Fan… - Frontiers in immunology, 2021 - frontiersin.org
… into tumor tissues through stromal-derived factor-1 (SDF-1) to promote angiogenesis (47).
CAFs degrade the extracellular stroma by releasing some matrix remodeling … of tumor cells. By …
CAFs degrade the extracellular stroma by releasing some matrix remodeling … of tumor cells. By …
Cancer-associated fibroblasts: mechanisms of tumor progression and novel therapeutic targets
RP Czekay, DJ Cheon, R Samarakoon, SM Kutz… - Cancers, 2022 - mdpi.com
… The leading cell in this motile cohort is usually a fibroblast that, unlike the follower tumor
cells, employs Rho-ROCK signaling and protease-mediated stromal remodeling to effectively …
cells, employs Rho-ROCK signaling and protease-mediated stromal remodeling to effectively …