Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches

S Esposito, G De Simone, G Boccia, F De Caro… - Journal of global …, 2017 - Elsevier
… Despite advances in management, sepsis and septic shock still … and therapeutic approaches
of sepsis and septic shock. … and to more aggressive therapeutic approach, including earlier …

Sepsis: from historical aspects to novel vistas. Pathogenic and therapeutic considerations

T Magrone, E Jirillo - Endocrine, Metabolic & Immune Disorders …, 2019 - ingentaconnect.com
sepsis is propaedeutic to the illustration of novel therapeutic attempts for the prevention or
attenuation of experimental sepsis … new therapeutic approaches for the treatment of sepsis will …

[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts

D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
… an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches
targeting different immunological mechanisms in the course of sepsis and septic shock, …

A rational approach to fluid therapy in sepsis

P Marik, R Bellomo - BJA: British Journal of Anaesthesia, 2016 - academic.oup.com
… that this approach does not improve the outcome of patients with severe sepsis and septic
… with sepsis and provides a rational approach to fluid management in this complex disorder. …

The endothelial glycocalyx: new diagnostic and therapeutic approaches in sepsis

L Martin, P Koczera, E Zechendorf… - BioMed research …, 2016 - Wiley Online Library
… and sepsis severity. In this review, we highlight the crucial role of the glycocalyx in sepsis
as a … serving as hopeful therapeutic targets in sepsis‐associated multiple organ failures. …

Emerging therapeutic targets for sepsis

EW Tindal, BE Armstead, SF Monaghan… - … on therapeutic …, 2021 - Taylor & Francis
… clinically benefitted substantially from therapeutic approaches derived from reductionist
animal modeling including checkpoint proteins, designer T-cells, to name a few [Citation43–45]. …

[HTML][HTML] Sepsis-induced AKI: From pathogenesis to therapeutic approaches

FF He, YM Wang, YY Chen, W Huang, ZQ Li… - Frontiers in …, 2022 - frontiersin.org
therapeutic effects in sepsis-induced AKI. Hence, understanding the pathophysiology of
sepsis-induced AKI may help to develop novel therapeutics … new therapeutic approach for sepsis

Sepsis and coronavirus disease 2019: common features and anti-inflammatory therapeutic approaches

J Beltran-Garcia, R Osca-Verdegal… - Critical care …, 2020 - journals.lww.com
therapies). Here, because the potential use of anti-inflammatory therapies in the treatment
of COVID-19 patients, we revisited the previous use of these therapies in sepsis settings. …

[HTML][HTML] Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
… To cast light on sepsis pathogenesis and novel intervention therapeutic results, we systemically
… and focused on the molecular signaling pathways and intervention therapies in sepsis. …

[HTML][HTML] Immunological defects in neonatal sepsis and potential therapeutic approaches

SL Raymond, JA Stortz, JC Mira, SD Larson… - Frontiers in …, 2017 - frontiersin.org
… in sepsis (26). In this narrative review, we focus on the current … to sepsis and how this
knowledge may be used to improve our investigative and clinical approach to neonatal sepsis. …