Therapeutic targeting of the tumor microenvironment

L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
… analysis of the current therapies targeting the TME, combining a discussion of the underlying
basic biology with clinical evaluation of different therapeutic approaches, and highlighting …

Targeting tumor microenvironment for cancer therapy

C Roma-Rodrigues, R Mendes, PV Baptista… - International journal of …, 2019 - mdpi.com
… The improvement in the efficacy of cancer therapeutics will probably be based on the use
of combined therapies targeting all cell populations that cohabit in the TME. Novel tactics can …

Tumor microenvironment as a therapeutic target in cancer

Y Xiao, D Yu - Pharmacology & therapeutics, 2021 - Elsevier
… progress in targeting the tumor microenvironment in both … in targeting the tumor
microenvironment to achieve therapeutic … to better decipher the tumor microenvironment; and …

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

S Thakkar, D Sharma, K Kalia, RK Tekade - Acta biomaterialia, 2020 - Elsevier
… We highlight the potential of tumor microenvironment; its role in disease progression, …
effective cancer therapy by conceptual understanding of tumor microenvironment and epigenetic …

Therapeutic targeting of MicroRNAs in the tumor microenvironment

R Raue, AC Frank, SN Syed, B Brüne - International journal of molecular …, 2021 - mdpi.com
… Their drug RGLS5579 aims to target miR-10b in glioblastoma multiforme, where it has been
identified as a promising therapeutic target [311]. In their current study, they aim to confirm …

Underlying causes and therapeutic targeting of the inflammatory tumor microenvironment

EA Comen, RL Bowman, M Kleppe - Frontiers in cell and …, 2018 - frontiersin.org
… of tumor suppressors. In this review, we examine the concept of the tumor microenvironment
… response and the tumor microenvironment may shed light on new therapies for both primary …

Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting

B Chaudhary, E Elkord - Vaccines, 2016 - mdpi.com
therapies. In this review, we critically examine the role of Tregs in the tumor microenvironment
and … of current therapeutic modalities on Treg biology and the therapeutic opportunities for …

[HTML][HTML] Updates on the hematologic tumor microenvironment and its therapeutic targeting

D Forte, DS Krause, M Andreeff, D Bonnet… - …, 2019 - ncbi.nlm.nih.gov
In this review article, we present recent updates on the hematologic tumor microenvironment
following the 3 rd Scientific Workshop on the Haematological Tumour Microenvironment

Tumor microenvironment and therapeutic response

T Wu, Y Dai - Cancer letters, 2017 - Elsevier
target tumor cells and the microenvironment may represent a solution to overcome
therapeutic … The possible anti-EM-DR therapeutic targets include extracellular ligand-receptor …

Therapeutic targets and tumor microenvironment in colorectal cancer

G Gallo, G Vescio, G De Paola… - Journal of Clinical …, 2021 - mdpi.com
… Currently, therapy targeted at CAFs is mainly aimed at reducing oxidative stress, a mediator
of the metabolic symbiosis between CAFs and tumor cells, and TGF-β [53,54,55]. Regarding …