… [ 18 F] thymidine derivatives uptake can be used to study cell proliferation in both in vitro
culture [Citation12,Citation58] and xenografts [Citation59] making it a translatable biomarker. …

… used as oral anti-cancer drugs in combination with thymidine phosphorylase inhibitor in the
treatment of refractory colorectal cancer. [ Citation 26 ] Upon uptake into the cells TFT can be …

… enzymes thymidylate synthase (TS) and thymidine kinase 1 (TK1) was evaluated in …
Pretreatment with FdUrd strongly increased the cellular uptake and the DNA incorporation …

… cell proliferation. [ 18 F]FLT is phosphorylated, and consequently trapped in cells, by thymidine
kinase … maximum in the late G1 and S phases of the cell cycle [2]. However, although [ 18 …

… Metabolic alterations that are critical for cancer cell growth and metastasis are one of the
key hallmarks of cancer. Here, we show that thymidine kinase 1 (TK1) is significantly …

… In the present study including 19 patients with newly diagnosed gliomas, all but two showed
focally increased 4DST uptake. Efficient cellular uptake requires the presence of specialized …

… ), where it is phosphorylated by thymidine kinase 1 (TK1). As an alternative … thymidine is
degraded. Consequently, lower amounts of thymidine compete with [ 18 F]FLT for cellular uptake …

… Using a large-scale transcriptomic database and survival correlation screening, we identify
thymidine kinase 1 (TK1) as a key driver. The progression of HCC is robustly mitigated by …

… TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2),
a critical enzyme in the mitochondrial nucleotide salvage pathway. Deficiency of TK2 activity …

… of thymidine kinases from the TK1 family. A, alignment overview of TK1 family members
including thymidine kinases … performed with three of the thymidine kinases. The G. intestinalis …