… by human nucleoside transporters, probably mainly by the human equilibrative nucleoside
… within the cytosol after being monophosphorylated by thymidine kinase-1 (TK1), one of the …

… using herpes simplex virus thymidine kinase (HsvTK) and the mutagenic nucleoside analog
6-(β-d-2… We found that over-expression of NupC and NupG (nucleoside uptake-related inner …

… used as oral anti-cancer drugs in combination with thymidine phosphorylase inhibitor in the
treatment of refractory colorectal cancer. [ Citation 26 ] Upon uptake into the cells TFT can be …

… Extensive preclinical studies of the reporter gene Herpes simplex viral thymidine kinase 1
(… in vitro uptake assays of five reporter probes to compare four human nucleoside reporter …

… Unlike uridine phosphorylase and thymidine … and thymidine as substrates. U or dU are
then phosphorylated to UMP or dUMP by uridine kinase [EC 2.7.1.48] or thymidine kinase (TK) […

… , [ 18 F]FLT is transported into cells, primarily via the human equilibrative nucleoside …
thymidine kinase 1 (TK1). As an alternative thymidine-to-DNA pathway, phosphorylated thymidine …

… are foremost responsible for the uptake of nucleosides and nucleoside analogues into cells
[… by nucleoside transporters. Once inside the cell, [18F]FLT is a substrate for thymidine kinase …

… protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage
… , indicating that despite nucleoside transport across the BBB, uptake efficiency is lower for …

… to select for a nucleoside kinase’s activity by transporting the kinase to the periplasmic …
Our proof-of-principle studies demonstrate that the herpes simplex virus thymidine kinase (HSV-…

… Figure 1Nucleotide metabolism in G. intestinalis. The parasite lacks many pathways in
nucleotide metabolism including ribonucleotide reductase (RNR) and thymidylate synthase (TS), …