[HTML][HTML] The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics

D Jang, AH Lee, HY Shin, HR Song, JH Park… - International journal of …, 2021 - mdpi.com
… induces the proliferation and anti-apoptosis of keratinocytes via the NF-κB signal pathway,
eventually leading to the formation of microabscess by enhancing the recruitment of …

… effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

MF Sun, YL Zhu, ZL Zhou, XB Jia, YD Xu… - Brain, behavior, and …, 2018 - Elsevier
… In summary, these results suggest that the TLR4/TBK1/NF-κB/TNF-α signaling pathway is
involved in gut inflammation and neuroinflammation, and further that FMT may improve gut …

Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways

C Li, Z Ma, L Jian, X Wang, L Sun, X Liu, Z Yao… - International …, 2021 - Elsevier
… with either RANKL or TNF-α plus M-CSF. The … of signal pathway was detected by Western
blotting. We used rodent models of osteoporosis (ovariectomy) and of arthritis (modified TNF-α-…

[HTML][HTML] The TNF-α/TNFR2 pathway: targeting a brake to release the anti-tumor immune response

A Moatti, JL Cohen - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
… infusion in patients initially led clinicians to abandon this signaling pathway as … TNF-α
pathway a promising anti-cancer target. Here, we review the role of the TNFR2 signaling pathway

Role of the NFκB-signaling pathway in cancer

L Xia, S Tan, Y Zhou, J Lin, H Wang… - OncoTargets and …, 2018 - Taylor & Francis
… -signal-transduction pathways play a key role in cancer, and obstruction of or anomalies in
signaling pathways … Citation9 This review focuses on this NFκB-signaling pathway in tumors. …

Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-α signaling pathway

J Huang, K Peng, L Wang, B Wen… - Acta Biochimica et …, 2016 - academic.oup.com
… found that tumor necrosis factor-α (TNF-α) is clearly up-regulated. Furthermore, anti-TNF-α
in human leukemia cell via mitochondrial signaling pathways. Following the up-regulation of …

The role of JAK/STAT signaling pathway and TNF-α crosstalk in human colorectal cancer

N Erkasap, R Özyurt, M Özkurt, F Yaşar, S Erkasap… - Gene Reports, 2016 - Elsevier
… STAT signaling pathway in human colorectal tissue and we evaluated interactions with TNFα,
… We measured the mRNA levels of STAT1, TNF-α, TNF-α R1A, NFκB, and caspase-3 by RT-…

[HTML][HTML] Effect of NF-kB signaling pathway on the expression of MIF, TNF-α, IL-6 in the regulation of intervertebral disc degeneration

H Liang, X Yang, C Liu, Z Sun… - Journal of musculoskeletal …, 2018 - ncbi.nlm.nih.gov
… kB signaling pathway and … TNF-α, and IL-6 was positively correlated with the expression of
NF-kB. It is well proved that the NF-kB pathway regulates downstream target genes MIF, TNF-α

[HTML][HTML] Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity

D Yang, X Tan, Z Lv, B Liu, R Baiyun, J Lu, Z Zhang - Scientific Reports, 2016 - nature.com
… dietary luteolin via regulating Sirt1/Nrf2/TNF-α signaling pathway, and provide a foundation
for further study of luteolin as a novel therapeutic agent against inorganic mercury poisoning. …

[HTML][HTML] The signaling pathway of TNF receptors: Linking animal models of renal disease to human CKD

I Lousa, F Reis, A Santos-Silva, L Belo - International Journal of …, 2022 - mdpi.com
… the TNF-α signaling pathway in CKD, as well as the associated-comorbidities. In a proteomic
analysis of human serum from patients with CKD, TNF-α … of the TNF signaling pathways. …