Macrophage polarization states in the tumor microenvironment

AJ Boutilier, SF Elsawa - International journal of molecular sciences, 2021 - mdpi.com
… Phosphatase and tensin homolog (PTEN) plays a key role in regulating the inflammatory
response through M1-polarization. Mice with a myeloid-specific PTEN knockout have been …

Macrophage polarization: the link between inflammation and related diseases

S Bashir, Y Sharma, A Elahi, F Khan - Inflammation research, 2016 - Springer
… The role of SHIP-1 in macrophage polarization in case of tumours has not been well
elucidated yet; it can be a therapeutic target of immense importance in cancer drug research. …

Tumor− associated macrophage polarization in the inflammatory tumor microenvironment

Z Zou, H Lin, M Li, B Lin - Frontiers in oncology, 2023 - frontiersin.org
Tumors are also considered ‘… inflammatory and imbalanced polarization of macrophages
(7–9). The present review provides an overview of macrophage polarization in inflammatory

The impact of the tumor microenvironment on macrophage polarization in cancer metastatic progression

H Wang, MMH Yung, HYS Ngan, KKL Chan… - International journal of …, 2021 - mdpi.com
… To fulfill these multiple functions, macrophages are polarized from the inflammation status (…
tumor development, the microenvironmental factors involved in macrophage polarization, and …

Macrophage polarization: anti‐cancer strategies to target tumor‐associated macrophage in breast cancer

M Tariq, J Zhang, G Liang, L Ding… - Journal of cellular …, 2017 - Wiley Online Library
… In tumor microenvironments, the macrophages polarization mainly depends on the activity
of local cytokines. In details, Pro-inflammatory M1-like macrophages will be established to …

Lactic acid in macrophage polarization: The significant role in inflammation and cancer

H Zhou, XY Yan, W Yu, X Liang, X Du… - International reviews …, 2022 - Taylor & Francis
… These results were consistent with previous observations in tumors, where lactic acid
induced macrophage polarization by relying on MCT uptake or acted as a signal molecule to …

The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation

C Wang, X Wang, D Zhang, X Sun… - Oncology …, 2023 - spandidos-publications.com
… Among them, the macrophage polarization by miRNAs has also been widely concerned by
… in macrophage polarization, and as the marker for the treatment of tumors and inflammation, …

Macrophage polarization and meta-inflammation

C Li, MM Xu, K Wang, AJ Adler, AT Vella, B Zhou - Translational Research, 2018 - Elsevier
… alteration of macrophage polarization in meta-inflammation is … Meta-inflammation-altered
macrophage polarization has been linked to insulin insensitivity, atherosclerosis, inflammatory

Macrophage M1/M2 polarization

C Yunna, H Mengru, W Lei, C Weidong - European journal of …, 2020 - Elsevier
… In this review, we analyzed the mechanism of macrophage polarization from the tumor
themselves alter the inflammatory response and affect macrophage polarization. Nuclear …

Tumor-derived exosomes in the regulation of macrophage polarization

MS Baig, A Roy, S Rajpoot, D Liu, R Savai… - Inflammation …, 2020 - Springer
… A co-culture of non-polarized macrophages with normoxic exosomes or hypoxic exosomes
isolated from epithelial ovarian cancer cells showed macrophage polarization towards tumor