Uric acid in metabolic syndrome: does uric acid have a definitive role?

S Copur, A Demiray, M Kanbay - European journal of internal medicine, 2022 - Elsevier
… New genetic polymorphisms on multiple genes are … genetic polymorphisms of xanthine
oxidoreductase and xanthine dehydrogenase, enzymes involved in the metabolism of uric acid, …

[HTML][HTML] Association between glucokinase regulator gene polymorphisms and serum uric acid levels in Taiwanese adolescents

LJ Ho, CH Lu, RY Su, FH Lin, SC Su, FC Kuo… - Scientific Reports, 2022 - nature.com
uric acid levels on the basis of gender differences. Logistic and linear regression analyses
explored the role of GCKR in abnormal uric acid … ) allele of GCKR rs1260326 polymorphism is …

Uric acid and hypertension: a focused review and practical recommendations

B De Becker, C Borghi, M Burnier… - Journal of …, 2019 - journals.lww.com
genetic polymorphisms involved in the renal handling of uric acid and that suggest these
genes … More recent studies have investigated the relevance of genetic polymorphisms affecting …

Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong

YM Roman, KA Culhane-Pera, J Menk… - Personalized …, 2016 - Taylor & Francis
… Hyperuricemia is typically classified by serum uric acid (SUA) … Overproduction of uric acid
(UA) may be attributed to diets … or production of endogenous nucleic acids. While breakdown of …

APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population

C Wang, W Yan, H Wang, J Zhu, H Chen - Pharmacogenomics, 2019 - Taylor & Francis
… Therefore, this study aims to explore the association between the APOE gene polymorphism
and metabolic levels in patients with hypertension or CHD, which can better guide clinical …

[HTML][HTML] Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population

ST Cheng, S Wu, CW Su, MS Teng, LA Hsu… - Journal of the Formosan …, 2017 - Elsevier
polymorphism (SNP) rs2231142 is an important genetic factor for increased uric acid (UA) …
This investigation aimed to analyze the association between ABCG2 polymorphisms and …

The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study

D Zhang, M Yang, D Zhou, Z Li, L Cai, Y Bao, H Li… - Gene, 2018 - Elsevier
Uric acid is the end product of purine metabolism in humans and unbalanced serum uric
acid (SUA) levels have been observed to cause a variety of common disorders. Elevated SUA …

Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry

OP Khaliq, T Konoshita, J Moodely… - Hypertension in …, 2020 - Taylor & Francis
uric acid polymorphisms in pregnancy, however, they are similar to a previous study that
reported URAT 1 gene … urate transporter gene (URAT 1) is responsible for uric acid reabsorption …

[HTML][HTML] Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals

SK Cho, B Kim, W Myung, Y Chang, S Ryu, HN Kim… - Scientific Reports, 2020 - nature.com
… of SUA levels in the Korean population and evaluated the genetic effects on SUA levels
using imputed single-nucleotide polymorphism (SNP) chip data. We also calculated polygenic …

Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose

MB Carroll, DM Smith, TL Shaak - Rheumatology international, 2017 - Springer
uric acid (SUA) goal. We pursued genomic sequencing of XOI metabolism and clearance
genes to identify single-nucleotide polymorphisms (… SNPs in any of these genes to XOI dose. …