The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation

RCM Ferreira, DL de Almeida… - … Journal of Pain, 2022 - Wiley Online Library
Bckground Aripiprazole is an antipsychotic drug used to treat schizophrenia and bipolar
disorder. Recently, its peripheral analgesic component was evaluated, however, the …

The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation

RCM Ferreira, DL de Almeida… - … journal of pain …, 2022 - pubmed.ncbi.nlm.nih.gov
Bckground Aripiprazole is an antipsychotic drug used to treat schizophrenia and bipolar
disorder. Recently, its peripheral analgesic component was evaluated, however, the …

The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation.

RCM Ferreira, DL de Almeida, IDG Duarte… - European Journal of …, 2022 - europepmc.org
Methods The hyperalgesia was induced via intraplantar injection of prostaglandin E 2 in
mice and the nociceptive thresholds were evaluated using the paw pressure test. All drugs …